FLY-PHY

The molecular physiology and the evolution of a new pathway promoting developmental stability

Coordinatore	FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA    more  Organization address address: CAMPO MARTIRES DA PATRIA 130 city: LISBOA postcode: 1169 056 contact info Titolo: Dr. Nome: Sílvia Cognome: Costa Email: send email Telefono: +35 1 218803033 Fax: +35 1 218851920
Nazionalità Coordinatore	Portugal [PT]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-CIG
Funding Scheme	MC-CIG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-09-01   -   2017-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA  Organization address address: CAMPO MARTIRES DA PATRIA 130 city: LISBOA postcode: 1169 056 contact info Titolo: Dr. Nome: Sílvia Cognome: Costa Email: send email Telefono: +35 1 218803033 Fax: +35 1 218851920	PT (LISBOA)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Developmental stability is the ability of an organism to buffer given traits against environmental and intrinsic perturbations. This may involve physiological, temporal or behavioral adjustments to the developmental program. The processes leading to developmental stability have been particularly well studied in arthropods. For instance, if uncoordinated growth is induced in the larval imaginal discs (the precursors of adult appendages) of Drosophila flies, a transient delay in the onset of metamorphosis ensues, allowing extra time for all discs to achieve their species-specific size and proportion. How exactly this exquisite coordination between growth and developmental timing is achieved is not completely understood. Recently, others and us have identified a fly-specific insulin/IGF-I/relaxin peptide named Drosophila insulin-like peptide 8 (DILP8) that responds to uncoordinated imaginal tissue growth and delays the onset of metamorphosis by inhibiting, via an unknown mechanism, the biosynthesis of the major insect molting hormone, Ecdysone. Loss of dilp8 increases intra-individual asymmetry and yields individuals with a greater than normal range of size variation and time of maturation. Thus, DILP8 is a central player in the communication system that mediates the adjustments to promote developmental stability in Drosophila. Here, we plan to identify the mechanism of action of DILP8 and to understand how this new peptide became incorporated into a conserved tissue-stress sensing pathway. To reach these objectives, we will identify the target tissue/s that mediate DILP8 function(s), the signalling pathway that it acts through, and determine when it originated and became responsive to abnormal growth during dipteran evolution. Our results should provide insight into the poorly understood physiological mechanisms used for interorgan growth coordination, and maybe shed new light into the evolution of new signalling pathways.'