R'BIRTH

Brain Imaging Return to Health

Coordinatore	ABO AKADEMI    more  Organization address address: DOMKYRKOTORGET 3 city: ABO postcode: 20500 contact info Titolo: Ms. Nome: Siv Cognome: Holmgren Email: send email Telefono: +358 2 2153230
Nazionalità Coordinatore	Finland [FI]
Totale costo	4˙214˙310 €
EC contributo	4˙214˙310 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-ITN
Funding Scheme	MC-ITN
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-09-01   -   2017-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ABO AKADEMI  Organization address address: DOMKYRKOTORGET 3 city: ABO postcode: 20500 contact info Titolo: Ms. Nome: Siv Cognome: Holmgren Email: send email Telefono: +358 2 2153230	FI (ABO)	coordinator	1˙113˙376.44
2	LUNDS UNIVERSITET  Organization address address: Paradisgatan 5c city: LUND postcode: 22100 contact info Titolo: Prof. Nome: Marianne Cognome: Olsson Email: send email Telefono: +46 2224320 Fax: +46 2224200	SE (LUND)	participant	818˙275.48
3	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN  Organization address address: College Green - city: DUBLIN postcode: 2 contact info Titolo: Ms. Nome: Deirdre Cognome: Savage Email: send email Telefono: 35318961942 Fax: 35317071633	IE (DUBLIN)	participant	731˙116.88
4	Nome Ente NON disponibile  Organization address address: YLIOPISTONRANTA 1 E city: Kuopio postcode: 70211 contact info Titolo: Dr. Nome: Hannele Cognome: Juvaste Email: send email Telefono: +358 505113403	FI (Kuopio)	participant	489˙178.80
5	THE UNIVERSITY OF NOTTINGHAM  Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD contact info Titolo: Mr. Nome: Paul Cognome: Cartledge Email: send email Telefono: +44 115 95 15679	UK (NOTTINGHAM)	participant	307˙056.64
6	IMMUNOVIA AB  Organization address address: MEDICON VILLAGE city: LUND postcode: 223 81 contact info Titolo: Prof. Nome: Carl Cognome: Borrebaeck Email: send email Telefono: +46 46189798	SE (LUND)	participant	259˙925.16
7	Advanced Practical Diagnostics  Organization address address: Hertoginstraat 82 city: Turnhout postcode: 2300 contact info Titolo: Dr. Nome: Aye Mu Cognome: Myint Email: send email Telefono: +324 85326560	BE (Turnhout)	participant	230˙340.00
8	LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE  Organization address address: BRENNECKESTRASSE 6 city: MAGDEBURG postcode: 39118 contact info Titolo: Ms. Nome: Thekla Cognome: Thiel Email: send email Telefono: +49 391626391291	DE (MAGDEBURG)	participant	201˙800.72
9	BGI EUROPE INSTITUTE FOND  Organization address address: OLE MAALOES VEJ 3 city: KOBENHAVN N postcode: 2200 contact info Titolo: Mrs. Nome: Jue Cognome: Wang Email: send email Telefono: +45 22502043	DK (KOBENHAVN N)	participant	63˙239.88

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 Obiettivo del progetto (Objective)

'Extended lifespan is a new and permanent feature of human life globally. The demographic for population growth of persons over 60 years is predicted to expand by 70% and 400% respectively in developed and less developed regions during the coming decades. Ageing, is accompanied by cognitive decline and greater risk of depression and anxiety. Major drug companies have recently cutback significantly on development of drugs against brain disorders due to lack of new avenues of research. Thus the responsibility falls on academic labs to make breakthroughs to improve brain health. This consortium gathers experts on molecular mechanisms of age-associated pathologies including depressive disorders and anxiety, and neurodegeneration. Specifically, they focus on identification of stress-regulated molecules provoking neuronal death and hindering neurogenesis, and monitoring the consequences of these processes in human brain. The groups combine biological and medical imaging techniques with behavioral studies and proteomics to define molecular mechanisms of ageing and neurogenesis. Using biotechnology, they will create new tools to isolate neurogenic cells from aged brain, thus aiding research strategies an early stage. Four leading imaging infrastructures from across Europe selected from the ESFRI Eurobioimaging Proof-of Concept list have been selected as partners to facilitate this training and research program. Confocal and high-content imaging is used to define ageing pathways, proteomics and genomics to visualize effectors of pathological ageing, transgenic mice to study neurogenesis and MRI/MRS to identify and localize new depression-related parameters in select patient populations. This multi-faceted approach aims to (i) identify druggable targets and identify reagents to interfere with pathways contributing to depression and anxiety, and (ii) produce novel tools to image depression-associated events in brain, facilitating earlier diagnosis and intervention.'