TRANSGENERATIONALRNA

RNA-Mediated Inheritance of Acquired Traits

 Coordinatore TEL AVIV UNIVERSITY 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Israel [IL]
 Totale costo 1˙499˙999 €
 EC contributo 1˙499˙999 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-StG
 Funding Scheme ERC-SG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-02-01   -   2019-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY

 Organization address address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
Titolo: Dr.
Nome: Oded
Cognome: Rechavi
Email: send email
Telefono: 972524000000
Fax: +972 3 6409697

IL (TEL AVIV) hostInstitution 1˙500˙000.00
2    TEL AVIV UNIVERSITY

 Organization address address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
Titolo: Ms.
Nome: Lea
Cognome: Pais
Email: send email
Telefono: 97236406250

IL (TEL AVIV) hostInstitution 1˙500˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

first    small    rnas    inherited    virnas    transgenerational    environmental    suggest    propagation    progeny    mediate    viral    acquired    efforts    transmission    inheritance    rna    antiviral    rnai    generations    traits   

 Obiettivo del progetto (Objective)

'Inheritance of acquired traits is a topic of long-standing interest and controversy. While some of the classic Lamarckian ideas have been dismissed, more recent observations suggest that certain characteristics acquired by an animal during its lifetime might be transmitted to the next generations. Recently I described, for the first time in animals, a biological context in which acquired traits are inherited via small RNA molecules, which ignore the boundary between the soma and the germ line (“The Weizmann Barrier”). Specifically, I showed that the nematode C.elegans inherit an acquired trait, antiviral resistance, through transgenerational transmission of antiviral small RNAs (viRNAs), which mediate RNA interference (RNAi) (Cell, 2011). viRNAs, which protect the worm from viral propagation, pass down to many ensuing generations in a non-Mendelian manner, in the absence of their DNA template, and thus defend RNAi-deficient progeny from viral propagation. Here I suggest defining the rules that govern RNA-mediated transgenerational inheritance of acquired traits and exploring its contribution for the genetics of complex traits. My first efforts will be directed towards elucidating the mechanism behind transgenerational transmission of small RNAs; I established a well-defined system for monitoring transgenerational silencing that should allow unveiling of its genetic and biochemical basis. Second, I will examine whether responses to relevant environmental stresses carry on to the next generations so that the progeny is better prepared to cope with similar conditions. Lastly, I will explore whether sensing of environmental cues by the nervous system drives small RNA biogenesis, which transfer transgenerationally and mediate inheritance of neuronally-encoded traits. While the idea that RNA encodes for “Inherited Memory” sounds heretic at first, my preliminary efforts suggest that inherited small RNAs may indeed transmit information about ancestral acquired experiences.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

M2C (2014)

FOLLOWING THE MOST MASSIVE GALAXY CLUSTERS ACROSS COSMIC TIME

Read More  

BLOWDISOL (2012)

"BLOW UP, DISPERSION AND SOLITONS"

Read More  

MCATNNLO (2014)

High Precision Simulation of particle collisions at the LHC

Read More