NGIDD

Neuron-Glia Interactions in Nerve Development and Disease

Coordinatore	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM    more  Organization address address: 's Gravendijkwal 230 city: ROTTERDAM postcode: 3015CE contact info Titolo: Dr. Nome: Rini Cognome: De Crom Email: send email Telefono: +31 10 7043459 Fax: +31 10 7044743
Nazionalità Coordinatore	Netherlands [NL]
Sito del progetto	http://www.ngidd.eu/
Totale costo	3˙887˙956 €
EC contributo	3˙000˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-04-01   -   2012-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM  Organization address address: 's Gravendijkwal 230 city: ROTTERDAM postcode: 3015CE contact info Titolo: Dr. Nome: Rini Cognome: De Crom Email: send email Telefono: +31 10 7043459 Fax: +31 10 7044743	NL (ROTTERDAM)	coordinator	0.00
2	AXXAM SPA  Organization address address: VIA MEUCCI 3 city: BRESSO MILANO postcode: 20091 contact info Titolo: Dr. Nome: Luigi Cognome: Gavazzeni Email: send email Telefono: +39 02 2105629 Fax: +39 02 2105602	IT (BRESSO MILANO)	participant	0.00
3	FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR  Organization address address: Via Olgettina 60 city: MILANO postcode: 20132 contact info Titolo: Dr. Nome: Maria Rosa Cognome: Pedrazzi Email: send email Telefono: -26434808 Fax: -26433744	IT (MILANO)	participant	0.00
4	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Prof. Nome: Klaus-Armin Cognome: Nave Email: send email Telefono: -4607 Fax: -4608	DE (MUENCHEN)	participant	0.00
5	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 650 9023	UK (EDINBURGH)	participant	0.00
6	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Mr. Nome: Michael Cognome: Browne Email: send email Telefono: -13790 Fax: -14157	UK (LONDON)	participant	0.00
7	WEIZMANN INSTITUTE OF SCIENCE  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Talia Cognome: Tzahor Email: send email Telefono: -3996 Fax: -4135	IL (REHOVOT)	participant	0.00
8	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER  Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 contact info Titolo: Prof. Nome: Christian Cognome: Klämbt Email: send email Telefono: +49 251 832 1122 Fax: +49 251 832 4686	DE (MUENSTER)	participant	0.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'The characteristic appearance of white matter in the nervous system results from a remarkable cellular structure called myelin. This membraneous sheath is wrapped around axons by dedicated glial cells, thereby allowing the rapid propagation of impulses along the axons. The importance of the myelin sheath is underscored by the many neurological diseases that are caused by loss or destabilization of the myelin sheath, such as multiple sclerosis, leukodystrophies and peripheral neuropathies. The formation and maintenance of myelin by Schwann cells and oligodendrocytes results from close interactions between the neuron and glia cell. However, despite the vast importance of myelin to the normal physiological function of the nervous system, the molecular mechanisms underlying axon-glial communication in health and disease still remains largely unknown. In this collaborative project we aim to unravel these molecular mechanisms, discover novel molecules involved in neuron-glia communication and identify and test new targets for pharmaceutical intervention to aid the regenerative capacity of the nervous system.'

Introduzione (Teaser)

Many neuropathies such as multiple sclerosis result from the alteration in myelin,the protective insulating material around a nerve cell . High disease prevalence has triggered research towards understanding the role of glial cells, the so-called 'glue' of the nervous system, in production of a fully functional myelinated nerve cell.