MITDYN

Studies on the role of Plk1 localization and activity in the regulation of microtubule dynamics during mitosis

Coordinatore	THE UNIVERSITY OF EDINBURGH    more  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 651 4028
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-01-01   -   2017-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 651 4028	UK (EDINBURGH)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Mitosis is a critical phase of the cell cycle where chromosome are equally partitioned to daughter cells using the structure and forces from the mitotic spindle apparatus to power this process. The spindle is made of hundreds of dynamic microtubule polymers. Within the spindle, subpopulations of microtubules are tightly controlled by microtubule associated proteins and signaling gradients to achieve distinct properties and functions. Small perturbations to microtubules dynamics or these regulatory players can profoundly affect chromosome segregation and is associated with aneuploidy and genomic instability. Although many mitotic players have been identified, quantitative and mechanistic views of how they are regulated to control microtubule dynamics are missing. I propose to quantitatively define how different mitotic microtubule subpopulations are regulated in a space and time dependent manner. I have identified the kinetochore and centrosome-localized kinase Plk1 as a key factor in modulating microtubule dynamics. Using cell biology, advanced quantitative analysis and biochemistry, we will identify Plk1 substrates that modulate microtubule dynamics throughout mitosis. In addition, we will examine how a Plk1 locally regulates microtubules to create different microtubule populations. These studies will inform how genomic fidelity and chromosome segregation are ensured through maintaining accurate local and global microtubule dynamics.'