GALECTCOMPART

Endocytic Membrane Compartmentalization by Galectins

 Coordinatore INSTITUT CURIE 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore France [FR]
 Totale costo 2˙270˙054 €
 EC contributo 2˙270˙054 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-ADG
 Funding Scheme ERC-AG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-04-01   -   2019-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEW SOUTH WALES

 Organization address address: ANZAC PARADE
city: SYDNEY
postcode: 2052

contact info
Titolo: Ms.
Nome: Roslyn
Cognome: Mccann
Email: send email
Telefono: +61 2 9385 5208

AU (SYDNEY) beneficiary 345˙600.00
2    INSTITUT CURIE

 Organization address address: 26, rue d'Ulm
city: PARIS
postcode: 75248

contact info
Titolo: Mr.
Nome: Ludger
Cognome: Johannes
Email: send email
Telefono: +33 1 56 24 63 51

FR (PARIS) hostInstitution 1˙924˙454.00
3    INSTITUT CURIE

 Organization address address: 26, rue d'Ulm
city: PARIS
postcode: 75248

contact info
Titolo: Mrs.
Nome: Corinne
Cognome: Cumin
Email: send email
Telefono: +33 1 56 24 66 20
Fax: +33 1 56 24 66 27

FR (PARIS) hostInstitution 1˙924˙454.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

migration    clathrin    adaptor    biology    tubular    domains    gal    cell    mdash    cellular    endocytosis    adhesion    molecular    gsls    independent    galectins    membrane    cd    galectin    endocytic    cargo    hypothesis   

 Obiettivo del progetto (Objective)

'The contribution of clathrin-independent endocytosis to the cellular entry of signaling receptors, cell adhesion factors, and other cell surface molecules is well documented. However, how this process is initiated is still unknown. We have recently found that a cellular lectin, galectin-3 (Gal3), entered cells via morphologically distinct tubular structures, so-called clathrin-independent carriers (CLICs); Gal3 endocytosis was required for the uptake of the CLIC cargo CD44, a cell adhesion/migration factor; CD44 and Gal3 uptake required glycosphingolipids (GSLs); Gal3 induced tubular membrane invaginations in a GSL-dependent manner. Based on these findings we propose the groundbreaking hypothesis that Gal3 is an adaptor that clusters cargo proteins carrying defined carbohydrate modifications together with specific GSLs into nanoscale membrane environments whose mechanical properties drive the clathrin-independent formation of endocytic pits. In this program, we will first establish the compositional topology of endocytic galectin processes (Aim 1). The adaptor hypothesis will then be tested using innovative chemical biology tools (Aim 2). Quantitative models of cargo clustering and membrane shape changes will be developed on the basis of biophysical measurements and coarse grain simulations (Aim 3). Intravital imaging of endocytosis and cell migration in mice will finally explore how the functional link between galectins and GSLs contributes to wound healing in the colon (Aim 4). The molecular functions of galectins and GSLs in endocytosis — major unresolved questions in cellular membrane biology — will thereby be established, providing details from atomic arrangements via multi-molecular complexes and meso-scaled membrane domains to in vivo physiology. I am confident that this program will lead to the discovery of a new clathrin-independent endocytic mechanism by which different types of cargo are sorted to and internalized from specific membrane domains.'

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