DNAMEREP

The role of essential DNA metabolism genes in vertebrate chromosome replication

 Coordinatore IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE 

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 Nazionalità Coordinatore Italy [IT]
 Totale costo 1˙999˙800 €
 EC contributo 1˙999˙800 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-CoG
 Funding Scheme ERC-CG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-06-01   -   2019-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE

 Organization address address: "Via Adamello, 16"
city: MILAN
postcode: 20139

contact info
Titolo: Dr.
Nome: Vincenzo
Cognome: Costanzo
Email: send email
Telefono: +39 02574303875
Fax: +39 02574303231

IT (MILAN) hostInstitution 1˙999˙800.00
2    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE

 Organization address address: "Via Adamello, 16"
city: MILAN
postcode: 20139

contact info
Titolo: Mr.
Nome: Carlo
Cognome: Raimondi Cominesi
Email: send email
Telefono: +39 02574303256
Fax: +39 02574303231

IT (MILAN) hostInstitution 1˙999˙800.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

organisms    repair    origins    vertebrate    regions    genes    function    cell    dna    mechanisms    faithful    metabolism    survival    molecular    replication    genome    events    free    genomes    chromosomal   

 Obiettivo del progetto (Objective)

'Faithful chromosomal DNA replication is essential to maintain genome stability. A number of DNA metabolism genes are involved at different levels in DNA replication. These factors are thought to facilitate the establishment of replication origins, assist the replication of chromatin regions with repetitive DNA, coordinate the repair of DNA molecules resulting from aberrant DNA replication events or protect replication forks in the presence of DNA lesions that impair their progression. Some DNA metabolism genes are present mainly in higher eukaryotes, suggesting the existence of more complex repair and replication mechanisms in organisms with complex genomes. The impact on cell survival of many DNA metabolism genes has so far precluded in depth molecular analysis. The use of cell free extracts able to recapitulate cell cycle events might help overcoming survival issues and facilitate these studies. The Xenopus laevis egg cell free extract represents an ideal system to study replication-associated functions of essential genes in vertebrate organisms. We will take advantage of this system together with innovative imaging and proteomic based experimental approaches that we are currently developing to characterize the molecular function of some essential DNA metabolism genes. In particular, we will characterize DNA metabolism genes involved in the assembly and distribution of replication origins in vertebrate cells, elucidate molecular mechanisms underlying the role of essential homologous recombination and fork protection proteins in chromosomal DNA replication, and finally identify and characterize factors required for faithful replication of specific vertebrate genomic regions. The results of these studies will provide groundbreaking information on several aspects of vertebrate genome metabolism and will allow long-awaited understanding of the function of a number of vertebrate essential DNA metabolism genes involved in the duplication of large and complex genomes.'

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