ERBT

Fear Conditioning and Extinction in Anxious Youth: Identifying Neuro-cognitive Abnormalities and Their Relation to Pediatric Anxiety Treatment Outcomes

Coordinatore	UNIVERSITY OF HAIFA    more  Organization address address: "Mount Carmel, Abba Khoushi Blvd." city: HAIFA postcode: 31905 contact info Titolo: Mrs. Nome: Tsvia Cognome: Beker Email: send email Telefono: +972 4 8288485
Nazionalità Coordinatore	Israel [IL]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-CIG
Funding Scheme	MC-CIG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-04-01   -   2018-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF HAIFA  Organization address address: "Mount Carmel, Abba Khoushi Blvd." city: HAIFA postcode: 31905 contact info Titolo: Mrs. Nome: Tsvia Cognome: Beker Email: send email Telefono: +972 4 8288485	IL (HAIFA)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Anxiety disorders are the most common pediatric psychopathology. Despite therapeutic advances, treatment-resistance remains high, and progress towards early detection of at-risk populations has hindered. The proposed research aims to address this problem by targeting information-processing functions, specifically fear learning and extinction, in an effort to link pediatric anxiety to dysfunction in cognitive mechanisms and the underlying perturbed fear circuits. Study 1 will examine differences in fear learning, extinction and extinction recall in anxious and non-anxious children. Participants will complete a novel fear condition- extinction task in the psychophysiology laboratory. Several weeks later, they will undergo fMRI scanning probing two distinctive processes: threat memory and threat appraisal. Since such deficient extinction occurs only in symptomatic individuals, it may provide a novel therapeutic target. Study 2 will demonstrate the therapeutic relevance by examining a link between impairments in extinction learning and exposure treatment outcomes. Exposure therapy is one of the most effective interventions for anxiety disorders. This intervention relies heavily on extinction learning principles and may produce beneficial effects by altering function in ventro-medial prefrontal cortex (vmPFC). Study 2 will assess vmPFC function in anxious adolescents prior to exposure therapy. A reduced vmPFC activation pre-exposure intervention is expected to predict a stronger response to exposure intervention, thereby moderating treatment outcome. The proposed study extends innovative translational work in animals and humans by examining specific neuro-cognitive mechanisms associated with pediatric anxiety. This study will yield clinically important data, which could ultimately advance early diagnosis of children at-risk for anxiety and improve treatment.'