MOLEGRO

A stochastic model of eye lens growth with implications for cortical cataract formation

 Coordinatore FACULTY OF SCIENCE UNIVERSITY OF ZAGREB 

 Organization address address: Horvatovac 102a
city: ZAGREB
postcode: 10000

contact info
Titolo: Prof.
Nome: Damir
Cognome: Bakic
Email: send email
Telefono: +385 14605701

 Nazionalità Coordinatore Croatia [HR]
 Totale costo 336˙315 €
 EC contributo 336˙315 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IOF
 Funding Scheme MC-IOF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-09-01   -   2017-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FACULTY OF SCIENCE UNIVERSITY OF ZAGREB

 Organization address address: Horvatovac 102a
city: ZAGREB
postcode: 10000

contact info
Titolo: Prof.
Nome: Damir
Cognome: Bakic
Email: send email
Telefono: +385 14605701

HR (ZAGREB) coordinator 336˙315.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

zagreb    mathematical    life    cells    affects    univ    bassnett    years    mathematics    lens   

 Obiettivo del progetto (Objective)

'Humans have lenses in their eyes; to focus light on the retina. The lens must be precisely built, flexible, and remain transparent throughout life. If anything fails, our ability to see is seriously affected. Lack of flexibility affects practically everyone over the age of 50. Cataract affects transparency and is the most common cause of blindness in the world. The biological lens grows throughout life, via a complex, but still regular process. Starts with some 350 mitotically-active cells and reaches some 7 million cells in a 60 year old human. How to describe and understand such a remarkable process? What is its effect on pathological developments? Even data collection looks extremely difficult, while the sheer complexity of the problem requires truly interdisciplinary approach, including the help of advanced mathematics. Thanks to the unprecedented technological development, it is now possible to label single cells within the eye lens, and to follow the path of its daughter cells. The Bassnett lab at Washington Univ School of Medicine is the leader in this labelling technique and has a very ambitious program to answer questions above. Two years ago we joined Prof. Steven Bassnett in this fascinating endeavor. We bring more than 20 years of research experience in probability theory and mathematical analysis, leadership on several NSF grants, as well as more than 10 years of leading the Division of Prob. & Stats, Dept of Mathematics, Univ of Zagreb. We propose to develop mathematical models of various stages in the growth of the lens. Initial period of our collaboration is completed and we are now at the level where daily contact is needed. Our model is Markov in nature, and would involve branching processes with immigration and emigration. At the ultimate level we need to consider also measure-valued processes, technically a highly demanding topic. We plan to return to Zagreb and fully develop student program and research group in biomedical mathematics.'

Altri progetti dello stesso programma (FP7-PEOPLE)

MECCA (2008)

Mediterranean Coral Calcification in response to global change

Read More  

EPONIMOS (2008)

Exhaust Particle Number and Mass Measurement and Sampling System

Read More  

PRESUME (2014)

Economies of Uncertainty: Epistemological Perspectives on the Reform of the Metric System

Read More