NANOHAPY

Nanomedicine and Hadrontherapy

 Coordinatore CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Véronique
Cognome: Debisschop
Email: send email
Telefono: +33 1 69823264
Fax: +33 1 69823333

 Nazionalità Coordinatore France [FR]
 Totale costo 194˙046 €
 EC contributo 194˙046 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-05-01   -   2016-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Véronique
Cognome: Debisschop
Email: send email
Telefono: +33 1 69823264
Fax: +33 1 69823333

FR (PARIS) coordinator 194˙046.60

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

nps    induced    medical    limited    damage    treatments    tumour    cancer    radiotherapy    community    cellular    patients    hadrontherapy    nanoparticles   

 Obiettivo del progetto (Objective)

'Cancer is one of the most feared diseases. Radiotherapy is commonly used in about 50% of all cancer patients. Although the radiotherapeutic protocols have been improved significantly, only a limited number of patients are entirely cured and severe side effects are often induced. Hadrontherapy and protontherapy are approaches superior to conventional photon radiotherapy because of the maximal energy they deposit at the end of the track (the Bragg peak) and the absence of damage induced behind the tumor. However, the technique is limited by the damage caused along the beam path in healthy tissue located in front of the tumour. Dr. Lacombe's work focuses on improving the hadrontherapy performances using metal nanoparticles (NPs) as radiosensitizers. This is a highly innovative strategy aiming at increasing efficiency and tumour targeting of the treatments. So far, the group focused on the physical properties of the nanoparticles. The objective of my project is to characterize fully the biological effects induced by NPs in DNA and living cells, submitted to medical ion radiations. During the project I will address the cellular toxicity, localization, uptake and quantification of NPs, and I will specifically dissect the cellular response to the combined treatment of NPs and fast ions/protons down to the molecular pathways. To answer these questions, I will make use of the highly advanced experimental instruments and methods available at the host institution and collaborating laboratories. The results obtained during this project will be highly relevant not only for the research community, but also for the industrial sector that synthetizes the NPs and for the medical community who will be closely involved in the project. This multidisciplinary research at the interface of physics, chemistry and biology is unique in Europe and promises novel propositions for future cancer treatments.'

Altri progetti dello stesso programma (FP7-PEOPLE)

NANOMAG-SQ (2013)

Magnetic imaging of individual nanomagnets

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X-RAY PUMP-PROBE (2010)

X-ray pump-probe spectroscopies - new tools to study ultrafast surface dynamics -

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GREEN ROOF SYSTEMS (2009)

Collaborative research and development of green roof system technology

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