INTEREXT

Interspecies endotheliarization for organ xenotransplantation

Coordinatore	FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA    more  Organization address address: AVENIDA DE PIO XII 55 city: PAMPLONA postcode: 31008 contact info Titolo: Mrs. Nome: Ana Cognome: Iglesias Email: send email Telefono: +34 948194700 Fax: +34 948194718
Nazionalità Coordinatore	Spain [ES]
Totale costo	223˙002 €
EC contributo	223˙002 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IEF
Funding Scheme	MC-IEF
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-04-01   -   2016-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA  Organization address address: AVENIDA DE PIO XII 55 city: PAMPLONA postcode: 31008 contact info Titolo: Mrs. Nome: Ana Cognome: Iglesias Email: send email Telefono: +34 948194700 Fax: +34 948194718	ES (PAMPLONA)	coordinator	223˙002.20

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Organ transplantation is an efficient approach or remedying end-life diseases that cannot be treated by other methods. Nevertheless, the available organs do not cover the clinical demand. As an alternative to the transplantation human organs, the xenotransplantation of animals’ organs has been proposed. Unfortunately, despite the big effort of the last decades, organs are severely rejected upon xenotransplantation, the endothelial cells (ECs) playing a fundamental role in this process. ECs are the first target of the immune system reactions; moreover molecular incompatibilities between host’s coagulation system and the exogenous ECs enhance thrombotic microangiopathy, which rapidly destroys the xenotransplanted organ. Therefore, we hypothesize that endotheliarization of the donor’s organs with cells of the future host may have an important effect on the rejection upon xenotransplantation. To prove this hypothesis, we propose to generate (mouse-ratEC) chimera by inter-species blastocyst complementation assay, which recently has been described effective for the generation of chimera animals between different species, and to determine the degree of rejection against the hearts of this chimera, once heterotopically xenotransplanted in rat. This project, which is based on mouse and rat systems, aims to deliver a proof of principle that, if obtained, will be further developed in clinically more relevant big animal models.'