OMVAC

Outer Membrane Vesicles (OMVs) from “Vaccinobacter”: A Synthetic Biology approach for effective vaccines against infectious diseases and cancer

 Coordinatore UNIVERSITA DEGLI STUDI DI TRENTO 

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 Nazionalità Coordinatore Italy [IT]
 Totale costo 2˙612˙828 €
 EC contributo 2˙612˙828 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-ADG
 Funding Scheme ERC-AG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-06-01   -   2019-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    EXTERNAUTICS SPA

 Organization address address: VIA FIORENTINA 1
city: SIENA
postcode: 53100

contact info
Titolo: Dr.
Nome: Paolo
Cognome: Sarmientos
Email: send email
Telefono: +39 335 5660142
Fax: +39 0577 43444

IT (SIENA) beneficiary 411˙000.00
2    UNIVERSITA DEGLI STUDI DI TRENTO

 Organization address address: VIA CALEPINA 14
city: TRENTO
postcode: 38122

contact info
Titolo: Dr.
Nome: Guido
Cognome: Grandi
Email: send email
Telefono: 390461000000
Fax: 390461000000

IT (TRENTO) hostInstitution 2˙201˙828.00
3    UNIVERSITA DEGLI STUDI DI TRENTO

 Organization address address: VIA CALEPINA 14
city: TRENTO
postcode: 38122

contact info
Titolo: Mrs.
Nome: Vanessa
Cognome: Ravagni
Email: send email
Telefono: +39 0461 281238
Fax: +39 0461 281128

IT (TRENTO) hostInstitution 2˙201˙828.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

immune    outer    omvs    foreign    vaccinobacter    molecular    immunity    antigens    vaccines    bacterial    pathogens    membrane    protective    cancer    potentially    create    proteins    pathogen   

 Obiettivo del progetto (Objective)

'This proposal intends to apply Synthetic Biology to create a new bacterial species, Vaccinobacter, devoted to the production of multivalent, highly effective vaccines. The project originates from the evidence that Outer membrane Vesicles (OMVs) naturally produced by all Gram-negative bacteria can induce remarkable protective immunity, a property already exploited to develop anti-Neisseria vaccines now available for human use. OMV protection is mediated by the abundance of Pathogen-Associated-Molecular Patterns (PAMPs), known to play a key role in stimulating innate immunity. Moreover, OMVs can be engineered by delivering recombinant proteins to bacterial periplasm and outer membrane. Intrinsic adjuvanticity and propensity to be manipulated potentially make OMVs an ideal vaccine platform, particularly indicated when antigen combinations (for pathogens with genetic variability) and strong potentiation of immunity (for the elderly and cancer) are needed. However, full exploitation of OMVs as vaccines is prevented by: i) presence of potentially reactogenic compounds such as LPS, virulence factors, and toxins, ii) presence of several irrelevant proteins, which dilute immune responses, iii) lack of broadly applicable molecular tools to load OMVs with foreign antigens. Scope of the project is to provide novel solutions to solve these limitations and demonstrate the unique performance OMVs as vaccines by testing them on complex pathogens and cancer. Main project activities are: 1) remodelling of E. coli genome to create “Vaccinobacter”, a “living factory” of OMVs deprived of all unnecessary components but carrying the relevant immune potentiators, 2) characterization and optimization of the immune stimulatory properties of OMVs, 3) development of novel methods to incorporate foreign antigens into Vaccinobacter-derived OMVs, 4) loading of OMVs with selected pathogen- and cancer-derived antigens and demonstration of their protective efficacy in appropriate animal models.'

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HISTANTARTSI (2011)

"Historical memory, Antiquarian Culture and Artistic Patronage: Social Identities in the Centres of Southern Italy between the Medieval and Early Modern Period"

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SIRAID (2009)

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HEPCENT (2009)

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