MITOSHAPE

Structural basis of mitochondrial inner membrane shape and dynamic

 Coordinatore MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT 

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 Nazionalità Coordinatore Germany [DE]
 Totale costo 1˙999˙972 €
 EC contributo 1˙999˙972 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-CoG
 Funding Scheme ERC-CG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-07-01   -   2019-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT

 Organization address address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125

contact info
Titolo: Dr.
Nome: Ioannis
Cognome: Legouras
Email: send email
Telefono: +49 3094064247
Fax: +49 30940649105

DE (BERLIN) hostInstitution 1˙999˙972.20
2    MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT

 Organization address address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125

contact info
Titolo: Prof.
Nome: Oliver
Cognome: Daumke
Email: send email
Telefono: +49 3094063425
Fax: +49 3094062158

DE (BERLIN) hostInstitution 1˙999˙972.20

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

im    shown    mutations    components    crista    dynamics    structures    ray    crystallographic    membrane    opa    structure    shape    mechanism    minos    cristae    determined    sam    fusion    junction    junctions    functions    mechanisms    mitochondrial      

 Obiettivo del progetto (Objective)

'Here, I propose to study the structure and mechanisms of the cellular machineries mediating the shape and dynamics of the mitochondrial inner membrane (IM). The mitochondrial IM contains membrane invaginations called cristae. These are connected by tubular openings, the crista junctions, to the remaining IM. Mitochondrial shape constantly changes due to membrane fission and fusion events, and a balance of both processes is required for proper functioning of mitochondria. Abnormal mitochondrial shape and altered dynamics are associated with severe diseases, such as cancer and neurodegeneration. Sourcing my group’s expertise in dynamin superfamily GTPases, I wish to understand the molecular mechanisms of how OPA1 can achieve mitochondrial IM fusion and cristae formation. To this end, the X-ray crystallographic structure of OPA1 will be determined and complemented by a comprehensive biochemical characterization. Cell-based assays will be employed to decipher the exact mechanism by which OPA1 carries out its two functions and how specific mutations in OPA1 disturb these processes and, thereby, induce human disease. The multiprotein MINOS complex was recently shown to be involved in the formation of crista junctions. I propose to explore the architecture of the MINOS complex. To this end, X-ray crystallographic structures of single components, subcomplexes and, eventually, the complete complex will be determined. Based on these structures, the mechanism of MINOS in mitochondrial membrane remodeling and crista junction formation will be dissected using a structure-based mutagenesis approach. Components of MINOS were shown to interact with OPA1 and with the sorting and assembly machinery (SAM) of the outer mitochondrial membrane. The interactions of MINOS with OPA1 and SAM will be biochemically mapped and structurally characterized. To understand their functions, the effect of disrupting mutations on crista junction formation and mitochondrial dynamics will be explored.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

SUMO (2008)

Study of the role of protein posttranslational modification by SUMO (Small Ubiquitin-like MOdifier) in abscisic acid signaling and stress responses in plants

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HI-DIM COMBINATORICS (2013)

High-dimensional combinatorics

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DEVSPACE (2012)

The development of the hippocampal spatial representation system

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