CRITICALSLEEP

Critical transitions and self-organization in sleep micro-architecture

 Coordinatore BAR ILAN UNIVERSITY 

 Organization address address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900

contact info
Titolo: Ms.
Nome: Estelle
Cognome: Waise
Email: send email
Telefono: +9723 5317439
Fax: +9723 6353277

 Nazionalità Coordinatore Israel [IL]
 Totale costo 256˙148 €
 EC contributo 256˙148 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-10-01   -   2016-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY

 Organization address address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900

contact info
Titolo: Ms.
Nome: Estelle
Cognome: Waise
Email: send email
Telefono: +9723 5317439
Fax: +9723 6353277

IL (RAMAT GAN) coordinator 256˙148.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

self    stage    disorders    organization    healthy    durations    soc    stimuli    equilibrium    sleep    humans    random    behavior    arousals    basic    dynamics    exhibit   

 Obiettivo del progetto (Objective)

'Humans and animals exhibit brief awakenings from sleep (arousals), which are traditionally viewed as random disruptions of sleep caused by external stimuli or pathologic perturbations. However, our recent findings show that arousals represent previously unrecognized intrinsic aspects of sleep, and exhibit complex temporal organization and scale-invariant behavior characterized by a power-law probability distribution for their durations. In contrast, sleep-stage durations exhibit exponential behavior. The co-existence of these two very different processes in the sleep regulatory mechanism has not been observed in any other physiological system, and resembles a special class of non-equilibrium physical systems exhibiting self-organized criticality (SOC). Such organization of arousals makes it unlikely that they are merely a response to random stimuli, however, the role arousals play in healthy sleep and in sleep disorders remains unknown.

Since our preliminary analyses show that SOC-type dynamics persist throughout the sleep period in humans and across several mammalian species with different sleep architecture, we hypothesize that arousals are an integral part of healthy sleep and relate to basic neuronal interactions. To address this hypothesis we will combine human sleep data and bio-molecular/genetic animal experiments with modern approaches from statistical physics of non-equilibrium systems and the theory of complex networks. Our objective is to uncover basic principles of self-organization in sleep that would elucidate the interrelation between sleep-stage dynamics and arousals, and to derive novel and more sensitive diagnostic markers of sleep disorders.'

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