ENOLAR

Arylation and Vinylation of Enolates: New Reactivity from the Urea Linkage

 Coordinatore THE UNIVERSITY OF MANCHESTER 

 Organization address address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL

contact info
Titolo: Ms.
Nome: Liz
Cognome: Fay
Email: send email
Telefono: 441613000000

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 221˙606 €
 EC contributo 221˙606 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-04-01   -   2016-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER

 Organization address address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL

contact info
Titolo: Ms.
Nome: Liz
Cognome: Fay
Email: send email
Telefono: 441613000000

UK (MANCHESTER) coordinator 221˙606.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

natural    vinylation    enolate    enolates    metal    arylation    reactions    amino    acids    aryl    acid    quaternary    reaction    versatile    simple    coupling    synthesis   

 Obiettivo del progetto (Objective)

'Enols and enolates are among the most versatile nucleophiles in chemistry: they react well with alkylating agents or carbonyl compounds, but their coupling with aryl or alkenyl halides is usually dependent on Pd-based catalysts for enol–aryl coupling. In this proposal we aim to develop new possibilities for enolate arylation that reveal fundamental new reactivity and will have repercussions throughout the science of synthetic planning. The method builds on some arylation reactions of urea-containing organolithiums, first reported in 2007, which turn out to be general for a variety of compound classes. Preliminary experiments show that enolates also undergo this arylation, providing a simple way of introducing an Ar equivalent to an enolate nucleophile without the need for heavy-metal catalysis. We propose to develop this reaction into a simple and versatile method for the challenging arylation of enolates. The resulting transformation will have broad application to the synthesis of biologically active targets, both natural and non-natural, of value to the pharmaceutical, agrochemical and related fine chemicals industries. Extension beyond the amino acids could see the method rooted among the canon of enolate-based C–C bond forming reactions.

Key objectives are: • Arylation and vinylation of amino acids: We will optimise the enolate methodology for the synthesis of quaternary amino acid targets. • Controlling absolute configuration: We will develop an asymmetric version of the reaction (ideally based on chiral metal ligands, but alternatively other structures) for the enantioselective synthesis of quaternary amino acids. • Mechanistic investigation: Unravelling the remarkable mechanism of the reaction will throw light on other possible future directions for the research. • Extending to other carboxylic acid derivatives. • Arylation and vinylation of ketones and aldehydes. • Synthesis of valuable target molecules.'

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