TNBCHEMIRNET

Enhancing chemotherapy response in triple negative breast cancer (TNBC) by modulating miRNA-target network and identifying biomarkers of response

Coordinatore	Bilkent Üniversitesi    more  Organization address address: ESKISEHIR YOLU 8 KM city: ANKARA postcode: TR-06800 contact info Titolo: Prof. Nome: Cevdet Cognome: Aykanat Email: send email Telefono: 903123000000 Fax: 903123000000
Nazionalità Coordinatore	Turkey [TR]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-CIG
Funding Scheme	MC-CIG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-07-01   -   2018-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Nome Ente NON disponibile  Organization address address: ESKISEHIR YOLU 8 KM city: ANKARA postcode: TR-06800 contact info Titolo: Prof. Nome: Cevdet Cognome: Aykanat Email: send email Telefono: 903123000000 Fax: 903123000000	TR (ANKARA)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer and therapies are primarily limited to conventional chemotherapy. TNBC patients who respond to neo-adjuvant chemotherapy with a pathological complete response (pCR) have excellent 5-year survival (up to 94%). However, this represents the minority of TNBC patients (25-40%). The remaining patients have less than 60% 5-year survival due to aggressive relapse. Therefore, increasing the pCR rate of chemotherapy in TNBC holds great promise for improving survival. Furthermore, it is important to identify biomarkers to predict/stratify TNBC patients with higher probability of response to chemotherapy. Recently, microRNAs (miRNAs), which are 20-22 nucleotide small RNAs, emerged as master regulators of several oncogenic processes including therapy resistance and have great potential to be used as therapeutics due to their ability to repress several oncogenic proteins simultaneously. Moreover, miRNAs have also been shown to be promising biomarkers for diagnosis, prognosis and therapy response in cancer. Herein I propose to study the potential for modulation of miRNAs/their target networks to enhance the response to chemotherapy and to identify biomarker of chemotherapy response in TNBC. In this line, I will develop in vivo chemoresistant models using both xenografts and tumor transplants from an established TNBC mouse model. Combining whole genome miRNA/mRNA sequencing, bioinformatics and network biology, miRNAs/their target network involved in chemoresistance will be identified, and targeted to enhance the chemoresponse of TNBC models. Finally, the biomarker potential of identified miRNAs/targets in TNBC patient tumors will be tested with inter-(national) collaborations from two different countries. Overall, this interdisciplinary study will provide pre-clinical data to enhance chemotherapy response in TNBC and identify biomarkers stratifying patients with higher response rate to chemotherapy.'