DIABIMMUNE

Pathogenesis of Type 1 Diabetes - Testing the Hygiene Hypothesis

 Coordinatore HELSINGIN YLIOPISTO 

 Organization address address: YLIOPISTONKATU 4
city: HELSINGIN YLIOPISTO
postcode: 14

contact info
Titolo: Ms.
Nome: Katariina
Cognome: Vainio-Mattila
Email: send email
Telefono: +358 9 191 25043
Fax: +358 9 191 25044

 Nazionalità Coordinatore Finland [FI]
 Sito del progetto http://www.diabimmune.org/
 Totale costo 7˙697˙061 €
 EC contributo 5˙999˙900 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-03-01   -   2014-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO

 Organization address address: YLIOPISTONKATU 4
city: HELSINGIN YLIOPISTO
postcode: 14

contact info
Titolo: Ms.
Nome: Katariina
Cognome: Vainio-Mattila
Email: send email
Telefono: +358 9 191 25043
Fax: +358 9 191 25044

FI (HELSINGIN YLIOPISTO) coordinator 0.00
2    Nome Ente NON disponibile

 Organization address address: STENBACKINKATU 9
city: HELSINKI
postcode: 29

contact info
Titolo: Ms.
Nome: Anne
Cognome: Karikumpu
Email: send email
Telefono: +358 9 471 73454
Fax: +358 9 471 75404

FI (HELSINKI) participant 0.00
3    "Ministry of Health and Social Development, Karelian Republic of the Russian Federation"

 Organization address address: "Lenin Street, 6"
city: Petrozavodsk
postcode: 185035

contact info
Titolo: Dr.
Nome: Valentina
Cognome: Ulich
Email: send email
Telefono: -793728
Fax: -783628

RU (Petrozavodsk) participant 0.00
4    ACADEMISCH ZIEKENHUIS GRONINGEN

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Dr.
Nome: Elisabeth W.H.M.
Cognome: Eijdems
Email: send email
Telefono: +31(0)503637939
Fax: +31 (0)50-3632883

NL (GRONINGEN) participant 0.00
5    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Erika
Cognome: Von Mutius
Email: send email
Telefono: -51602749
Fax: -51604492

DE (MUENCHEN) participant 0.00
6    OU IMMUNOTRON

 Organization address address: Riia 185
city: TARTU
postcode: 51014

contact info
Titolo: Dr.
Nome: Raivo
Cognome: Uibo
Email: send email
Telefono: -5104707
Fax: -7382669

EE (TARTU) participant 0.00
7    Petrozavodsk State University

 Organization address address: LENIN STREET 33 33
city: PETROZAVODSK
postcode: 185640

contact info
Titolo: Prof.
Nome: Natalya
Cognome: Dorshakova
Email: send email
Telefono: -1523
Fax: -1520

RU (PETROZAVODSK) participant 0.00
8    SIHTASUTUS TARTU UELIKOOLI KLIINIKUM

 Organization address address: PUUSEPA 1A
city: TARTU
postcode: 50406

contact info
Titolo: Prof.
Nome: Vallo
Cognome: Tillmann
Email: send email
Telefono: +372 731 9500
Fax: +372 731 9503

EE (TARTU) participant 0.00
9    TAMPEREEN YLIOPISTO

 Organization address address: Kalevantie 4
city: TAMPERE
postcode: 33014

contact info
Titolo: Ms.
Nome: Hannele
Cognome: Auffermann
Email: send email
Telefono: -35515660
Fax: -35518615

FI (TAMPERE) participant 0.00
10    TARTU ULIKOOL

 Organization address address: ULIKOOLI 18
city: TARTU
postcode: 50090

contact info
Titolo: Prof.
Nome: Raivo
Cognome: Uibo
Email: send email
Telefono: +372 737 4231
Fax: +372 737 4232

EE (TARTU) participant 0.00
11    TERVEYDEN JA HYVINVOINNIN LAITOS

 Organization address address: MANNERHEIMINTIE 166
city: HELSINKI
postcode: 300

contact info
Titolo: Mr.
Nome: Jaakko
Cognome: Penttinen
Email: send email
Telefono: +358-9-4744 8203
Fax: +358-9-4744 8225

FI (HELSINKI) participant 0.00
12    TURUN YLIOPISTO

 Organization address address: YLIOPISTONMAKI
city: TURUN YLIOPISTO
postcode: 20014

contact info
Titolo: Dr.
Nome: Eliisa
Cognome: Särkilahti
Email: send email
Telefono: -3335799
Fax: -3336090

FI (TURUN YLIOPISTO) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

autoimmunity    country    age    populations    finland    russian    frequency    years    microbial    diseases    infections    mediated    karelia    functional    children    living    birth    data    flora    gut       cohort    immune    hla    standard    incidence    hygiene    dietary   

 Obiettivo del progetto (Objective)

'Preliminary data indicate that there is a strong association between the incidence of immune-mediated diseases and improving standard of living and hygiene. One of the steepest gradient in standard of living worldwide is present at the border between Russian Karelia and Finland with a sevenfold difference in the gross national product, while Estonia represents a country in rapid transition. These three populations comprise a “living laboratory” providing a unique possibility to test the hygiene hypothesis in the development of immune-mediated diseases. The incidence of type 1 diabetes (T1D) is six times lower in Russian Karelia than in Finland, whereas there are very limited differences in the frequency of risk HLA genotypes in the background population. This proposal aims at comparing (i) the frequency of beta-cell autoimmunity and other organ-specific autoantibodies; (ii) the frequency of IgE-specific sensitisation and signs of allergy; (iii) the frequency of various infections; (iv) the gut microbial flora; and (v) dietary intake in young children between the three populations. The birth cohort arm of the study aims at (i) delineating the ontogeny of the immune system by using modern tools of functional genomics; (ii) comparing the functional characteristics of regulatory T cells; (iii) characterising the gut microbial colonisation in infants; (iv) assessing the timing of exposure to foreign proteins in infancy (v) defining the interrelations between dietary factors, gut microbial flora and acute microbial infections. The objectives will be approached by studying 1600 children at the age of 3 and 5 years and by observing a birth cohort comprising about 320 subjects with HLA-conferred susceptibility to autoimmunity from birth up to the age of 3 years in each country. This proposal is expected to provide new data on the reasons and mechanisms behind the increasing rates of T1D and other immune-mediated diseases seen in most developed countries after World War II.'

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