ECSUB

Encoded Cellular Synthesis of Unnatural Biopolymers

 Coordinatore MEDICAL RESEARCH COUNCIL 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 1˙782˙918 €
 EC contributo 1˙782˙918 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2007-StG
 Funding Scheme ERC-SG
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2014-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Dr.
Nome: Jason William Karl
Cognome: Chin
Email: send email
Telefono: + 44 (0)1223 248011
Fax: + 44 (0) 1223 252970

UK (SWINDON) hostInstitution 0.00
2    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Ms.
Nome: Elizabeth
Cognome: Cutler
Email: send email
Telefono: +44 1223 402357
Fax: +44 1223 412515

UK (SWINDON) hostInstitution 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

protein    explore    translation    cells    amino    monomers    polymers    encoded    incorporation    orthogonal    living    vivo    unnatural   

 Obiettivo del progetto (Objective)

'We are building a parallel and independent (orthogonal) translational machinery for the encoded biosynthesis of unnatural polymers in living cells. The orthogonal translation system has many potential applications beyond those possible with the natural translation system: I propose to use it: 1) To expand the chemical scope of monomers that can be polymerized by the ribosome in living cells, allowing the incorporation of monomers with unnatural backbones into proteins; 2) To increase the efficiency of in vivo unnatural amino acid mutagenesis via amber suppression, so that no truncated protein is produced and multi-site incorporation of unnatural amino acids is possible; 3) To create probes of protein function for use in vivo; 4) To free numerous codons for simultaneous encoding of multiple distinct unnatural monomers, and to experimentally explore alternate genetic codes; 5) To explore the evolution of encoded unnatural polymers toward new cellular functions.'

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