ITT AND SPERM

Testosterone threshold required for spermatogenesis

 Coordinatore IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE 

 Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ

contact info
Titolo: Ms.
Nome: Deslyn
Cognome: Brown
Email: send email
Telefono: +44 20 8383 8339
Fax: +44 20 8383 2208

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 178˙307 €
 EC contributo 178˙307 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-2-1-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-07-15   -   2008-10-14

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

 Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ

contact info
Titolo: Ms.
Nome: Deslyn
Cognome: Brown
Email: send email
Telefono: +44 20 8383 8339
Fax: +44 20 8383 2208

UK (LONDON) coordinator 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

treatment    androgen    peripheral    yet    gonadotrophin    contraception    normal    residual    tested    replacement    experimental    actions    spermatogenesis    blockage    complete    itt    male    hormonal    dose    stimulating    arrest    contraceptive    suppression    efficacy   

 Obiettivo del progetto (Objective)

'Follicle-stimulating hormone and high intratesticular (IT) testosterone (T) level are required for qualitatively normal spermatogenesis. Treatment with T has been successfully tested in male contraception, because it can abolish gonadotrophin secretion through enhanced negative feedback action and arrest spermatogenesis. However, none of the T treatment regimens tested have resulted in complete azoospermia in all men, for reasons not yet understood. After complete T induced suppression of gonadotrophins, the residual ITT levels are 2% of normal, yet similar to those in peripheral circulation. The residual constitutively produced ITT could be the reason for the suboptimal contraceptive efficacy. The purpose of this study is to address in details the dependence of spermatogenesis and its suppression during contraceptive treatments on ITT level. The particular aim of this proposal will be to demonstrate in experimental conditions (mice) that the necessary peripheral androgen actions and spermatogenic arrest can be achieved simultaneously, which is fundamental for the functionality of an androgen based male hormonal contraceptive. The project will be articulated on three major objectives: (i) to determine the threshold of T replacement dose that maintains peripheral androgen actions without stimulating spermatogenesis; (ii) to design a way to suppress ITT production below the level achieved by gonadotrophin blockage, and (iii) to design a way to increase the efficacy and safety margin of T replacement dose by blockage of the constitutive T production. We expect that these experimental studies will show that it is important to eliminate the gonadotrophin independent component of ITT to maximise the efficacy of male hormonal contraception. In addition, this project permits the researcher to undertake the research with a view to completing and diversifying her expertise in molecular biology and endocrinology and pursue her career in academic research.'

Altri progetti dello stesso programma (FP7-PEOPLE)

TEMSPATH (2010)

Impact of temperature on the vulnerability of Mediterranean seagrasses to phatogens

Read More  

TASCLIM (2009)

High-resolution quantitative climate reconstructions for understanding current trends: the past 2000 years of Tasmanian climate variability

Read More  

MAGNAFACT (2009)

Fungal dimorphism and plant infection during Magnaporthe grisea – rice interaction

Read More