MULTI-PGNAS

Multifunctional Photothermal Gold Nanoarrays for Cellular Manipulation

 Coordinatore MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. 

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Richard
Cognome: Segar
Email: send email
Telefono: +49 (0)711 689 3474
Fax: +49 (0)711 689 3412

 Nazionalità Coordinatore Germany [DE]
 Totale costo 162˙096 €
 EC contributo 162˙096 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-2-1-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-07-15   -   2010-07-14

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Richard
Cognome: Segar
Email: send email
Telefono: +49 (0)711 689 3474
Fax: +49 (0)711 689 3412

DE (MUENCHEN) coordinator 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

period    interface    manipulate    gold    throughput    integrate    cell    releasing    time    substrates    pgnas    transportation    cells    functions    conduct    entities    living    attachment    photothermal    platform    millions    tests    guiding    nanoparticle    nanoparticles    designing    biological   

 Obiettivo del progetto (Objective)

'Transporting, organizing, attaching, guiding, releasing entities of various dimensions over different scales remain central to the development of high throughput biological devices able to conduct millions of tests in a short period of time. The proposed project intends to develop a new generation of substrates for cell manipulation based on photothermal processes. Specifically, it focuses on realizing standard and new functions related to tissue engineering and cell transportation by designing a single type of platform. This project aims to implement photothermal gold nanoparticle arrays (PGNAs) to physically manipulate various types of entities, like living cells. Each gold nanodot will play the role of an adhesive spot exposing the RGD peptide, which are separated by nonadhesive regions functionalized with poly(ethylene glycol) (PEG), so that cell-binding sites will exclusively interface the nanoparticle. By irradiating well-defined areas of the PGNAs with a focused laser beam, the fellow hopes to take advantage of the local heating generated by the nanoparticles to prevent cell attachment in these hot areas. This way, it is possible to study and integrate multiple functions in order to deliver one unique dynamic platform able to precisely control both cell adhesion (releasing, patterning, guiding) and cell transportation (via optofluidics) at the PGNA interface. The “Multi-PGNAs” project may permit to integrate the same nanotechnology for the development of modern applications, while providing innovative methodologies for designing new experiments in cell biology and nanophysics.'

Introduzione (Teaser)

High-throughput biological devices rely on the transport, attachment and release of various entities in order to conduct millions of tests in a short period of time. A European study utilised gold nanoparticles immobilized on glass substrates to capture and manipulate living cells, with the ultimate goal of implementing this technology in biomedical instrumentation.

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