MULTI-PGNAS

Multifunctional Photothermal Gold Nanoarrays for Cellular Manipulation

Coordinatore	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.    more  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Dr. Nome: Richard Cognome: Segar Email: send email Telefono: +49 (0)711 689 3474 Fax: +49 (0)711 689 3412
Nazionalità Coordinatore	Germany [DE]
Totale costo	162˙096 €
EC contributo	162˙096 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-07-15   -   2010-07-14

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Dr. Nome: Richard Cognome: Segar Email: send email Telefono: +49 (0)711 689 3474 Fax: +49 (0)711 689 3412	DE (MUENCHEN)	coordinator	0.00

Mappa

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 Obiettivo del progetto (Objective)

'Transporting, organizing, attaching, guiding, releasing entities of various dimensions over different scales remain central to the development of high throughput biological devices able to conduct millions of tests in a short period of time. The proposed project intends to develop a new generation of substrates for cell manipulation based on photothermal processes. Specifically, it focuses on realizing standard and new functions related to tissue engineering and cell transportation by designing a single type of platform. This project aims to implement photothermal gold nanoparticle arrays (PGNAs) to physically manipulate various types of entities, like living cells. Each gold nanodot will play the role of an adhesive spot exposing the RGD peptide, which are separated by nonadhesive regions functionalized with poly(ethylene glycol) (PEG), so that cell-binding sites will exclusively interface the nanoparticle. By irradiating well-defined areas of the PGNAs with a focused laser beam, the fellow hopes to take advantage of the local heating generated by the nanoparticles to prevent cell attachment in these hot areas. This way, it is possible to study and integrate multiple functions in order to deliver one unique dynamic platform able to precisely control both cell adhesion (releasing, patterning, guiding) and cell transportation (via optofluidics) at the PGNA interface. The “Multi-PGNAs” project may permit to integrate the same nanotechnology for the development of modern applications, while providing innovative methodologies for designing new experiments in cell biology and nanophysics.'

Introduzione (Teaser)

High-throughput biological devices rely on the transport, attachment and release of various entities in order to conduct millions of tests in a short period of time. A European study utilised gold nanoparticles immobilized on glass substrates to capture and manipulate living cells, with the ultimate goal of implementing this technology in biomedical instrumentation.