TOBIAS

THz Optics for Biological In-situ Analitical Spectroscopy

Coordinatore	more  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Francesca Cognome: Calvi Email: send email Telefono: +39 0106598788 Fax: +39 0106598732
Nazionalità Coordinatore	Non specificata
Totale costo	217˙645 €
EC contributo	217˙645 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-10-01   -   2011-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Francesca Cognome: Calvi Email: send email Telefono: +39 0106598788 Fax: +39 0106598732	IT (ROMA)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'This three years project is concerned with the development of a Near-field (NF) THz absorption spectroscopy system with specific reference to the real-time characterization of bio-matter. This system will exploit electromagnetic resonance fingerprints (i.e. characteristic spectral responses). µm and sub-µm resolution will enable to spatially discriminate important low-energy materials resonances in bio-samples. The proposed research will allow the team members from INRS-EMT and CNR-INFM-SOFT, and their partners from the Univ. of Montreal and from McGill Univ., to lead the efforts in searching novel non-invasive investigation techniques. Our efforts will require a multidisciplinary approach, focused towards the following objectives: A: The design of a novel geometry for coherent THz generation. In-situ generation (THz radiation is generated at the interface with the sample) will be used to overcome the common power limitation of NF methods (resulting from to the limited aperture of the NF tip probing). Differential techniques will be used for subtracting the inorganic component contribution. In addition elicity control of the generated THz will be implemented in order to increase the discrimination of bio-compounds. Finally, Temporal time-domain-spectroscopy will be used for measuring the sample spectral resonances. B:THz spectroscopy of biopolymers. Amino acids, Proteins and DNA possess specific THz global and sub-global modes. Joining the interest of the involved partners in mapping biological compounds our test benches will be the detection of fundamental amino acid like Tyrosine and a fundamental alpha protein like human insulin. C:Experiments to demonstrate our ability to spatially (sub-wavelength) map a micrometric structure properly designed for mimicking the application on real biological tissue'