ARTEMIP

THE SAFETY PHARMACOLOGY OF ARTEMISININS WHEN USED TO REVERSE PATHOPHYSIOLOGY OF MALARIA IN PREGNANCY

 Coordinatore LIVERPOOL SCHOOL OF TROPICAL MEDICINE 

 Organization address address: Pembroke Place
city: LIVERPOOL
postcode: L35QA

contact info
Titolo: Prof.
Nome: Stephen
Cognome: Ward
Email: send email
Telefono: +44 151 705 3286
Fax: +44 151 705 3371

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 2˙597˙331 €
 EC contributo 1˙948˙880 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-03-01   -   2011-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LIVERPOOL SCHOOL OF TROPICAL MEDICINE

 Organization address address: Pembroke Place
city: LIVERPOOL
postcode: L35QA

contact info
Titolo: Prof.
Nome: Stephen
Cognome: Ward
Email: send email
Telefono: +44 151 705 3286
Fax: +44 151 705 3371

UK (LIVERPOOL) coordinator 0.00
2    GOETEBORGS UNIVERSITET

 Organization address address: VASAPARKEN
city: GOETEBORG
postcode: 405 30

contact info
Titolo: Prof.
Nome: Michael
Cognome: Ashton
Email: send email
Telefono: +46 31 786 3412
Fax: +46 31 786 3284

SE (GOETEBORG) participant 0.00
3    THE UNIVERSITY OF LIVERPOOL

 Organization address address: Brownlow Hill, Foundation Building 765
city: LIVERPOOL
postcode: L69 7ZX

contact info
Titolo: Ms.
Nome: Veronica
Cognome: Cannings
Email: send email
Telefono: +44 151 794 8722
Fax: +44 151 794 8728

UK (LIVERPOOL) participant 0.00
4    UNIVERSIDADE DO ALGARVE

 Organization address address: CAMPUS DE PENHA
city: FARO
postcode: 8005 139

contact info
Titolo: Prof.
Nome: Maria De Lurdes
Cognome: Cristiano
Email: send email
Telefono: +35 1298 800 900
Fax: +35 1289 800 066

PT (FARO) participant 0.00
5    UNIVERSITEIT LEIDEN

 Organization address address: RAPENBURG 70
city: LEIDEN
postcode: 2300 RA

contact info
Titolo: Mr.
Nome: Ton
Cognome: Bouw Er
Email: send email
Telefono: +31 71 527 3149
Fax: +31 71 527 5269

NL (LEIDEN) participant 0.00
6    WORLD HEALTH ORGANIZATION.

 Organization address address: Avenue Appia 20
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Piero
Cognome: Olliaro
Email: send email
Telefono: +41 22 791 3734
Fax: +41 22 791 4774

CH (GENEVE) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

artemisinin    artemisinins    teratogenic    drug    drugs    human    species    hypothesis   

 Obiettivo del progetto (Objective)

'Artemisinin based antimalarial drug combinations are recommended for the treatment of P.falciparum malaria infections throughout all malarial endemic areas of the world and in all populations, including women of child bearing age. The studies planned in this collaborative project are central to assessing the potential hazard posed by these drugs to the developing human foetus and thereby making evidence based recommendations on the risk:benefit of these drugs. Although clinical experience to date indicates the artemisinins to be safe, the area of reproductive toxicology demands special consideration. Data from the Chinese literature and our own studies confirm that the artemisinins are embryotoxic and potentially teratogenic in animal species at drug doses within the human therapeutic range. Based on over ten years of investigating the pharmacology of these drugs we have developed a hypothesis which can explain these teratogenic effects. Our hypothesis is based on the generation of reactive oxygen species (ROS) from cleavage of the artemisinin peroxide bridge and consequent embryofoetal damage to key biological macromolecules. Our hypothesis draws on parallels with the metabolic activation and teratogenic effects of the other established teratogens such as phenytoin'

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