DIFFUSIVE XRAY

Time-resolved diffusive X-ray scattering for the study of cell membrane transport

Coordinatore	GOETEBORGS UNIVERSITET    more  Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 contact info Titolo: Dr. Nome: Ludde Cognome: Edgren Email: send email Telefono: -7862768 Fax: -7864340
Nazionalità Coordinatore	Sweden [SE]
Totale costo	177˙320 €
EC contributo	177˙320 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-05-01   -   2010-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	GOETEBORGS UNIVERSITET  Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 contact info Titolo: Dr. Nome: Ludde Cognome: Edgren Email: send email Telefono: -7862768 Fax: -7864340	SE (GOETEBORG)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'In this application we propose to apply the emerging tools of solution-phase, time-resolved X-ray scattering to the study of transfer phenomena in membrane transport proteins. Diffusive X-ray scattering of heavy metals in solution has recently been used by the host to monitor reaction kinetics of simple photochemical systems on a picosecond timescale. We seek to extend the technique to monitor structural dynamics inside the transport channel of halorhodopsin (hR), an important membrane protein that transports halides after photoactivation. The proposed experiment on hR will yield a movie of ion transport in the channel with the aim to clarify into the mechanism of trans-membrane ion transport. Success in the project will open new experimental windows for the study of basic cellular processes of tremendous scientific and biomedical importance.'