NUCLEIC ACIDS SENSOR

Molecular basis of the recognition of foreign nucleic acids in innate immunity

 Coordinatore FUNDACAO CALOUSTE GULBENKIAN 

 Organization address address: AVENIDA DE BERNA 45A
city: LISBOA
postcode: 1000

contact info
Titolo: Prof.
Nome: Antonio
Cognome: Coutinho
Email: send email
Telefono: -214407550
Fax: -214410501

 Nazionalità Coordinatore Portugal [PT]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IRG-2008
 Funding Scheme MC-IRG
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-12-01   -   2012-11-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FUNDACAO CALOUSTE GULBENKIAN

 Organization address address: AVENIDA DE BERNA 45A
city: LISBOA
postcode: 1000

contact info
Titolo: Prof.
Nome: Antonio
Cognome: Coutinho
Email: send email
Telefono: -214407550
Fax: -214410501

PT (LISBOA) coordinator 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cytoplasm    clarify    nucleic    domains    pathogen    dai    dna    interferon    activation    extensive    acids    biochemical    rna    context    molecular       recognition    structural    related    proteins   

 Obiettivo del progetto (Objective)

'The innate immunity system for vertebrates represents the front-end of their defense against invading viruses and bacteria. Its activation is based on the recognition of pathogen associated molecular patterns (PAMPs) by specialized receptors. Central in the pathogen recognition process is the detection of nucleic acids. However, how exactly foreign nucleic acids are distinguished from host DNA and RNA is poorly understood and of great importance since false recognition leads to severe auto-immune disorders. DAI is a protein which recently was identified as a receptor for dsDNA in the cytoplasm. It belongs to a small family of interferon response related proteins which share DNA/RNA binding domains called Z-domains due to their unusual ability to bind left-handed helices of nucleic acids. Here we propose structural and biochemical work aiming to clarify the molecular basis of the interaction of DAI with nucleic acids as well as to define the role of Z-domains in the context of the interferon inducible RNA editing enzyme ADAR1 and the viral inhibitor of interferon response E3L. This work will build upon extensive crystallographic, NMR and biochemical work on individual isolated Z-domains and aims to clarify how those domains combine and function in the context of the corresponding full length proteins. As part of this work the determination of the structure of DAI in complex with DNA is expected to become a powerful tool for the extensive immunological studies related to the interferon response activation by nucleic acids in the cytoplasm. The work is to be carried out in conjunction at two affiliated institutions: IGC and ITQB both located at Oeiras/Portugal, the first highly respected in immunology and the second in structural biology.'

Altri progetti dello stesso programma (FP7-PEOPLE)

COGEPRBN (2008)

Molecular characterization of the PrBn locus and some other QTLs controlling homeologous recombination in Brassica napus

Read More  

T3D3 STEM CELLS (2011)

Thyroid hormone and development of cardiomyocytes derived from human embryonic and induced pluripotent stem cells

Read More  

BROKERING (2014)

Employing the Cultural Broker in the Governance of Migration and Integration

Read More