DROSOERSTRESS

ER Stress and Photoreceptor Degeneration in Drosophila

Coordinatore	INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA    more  Organization address address: "Avenida da Republica, Estacao Agronomica Nacional" city: OEIRAS postcode: 2784-505 contact info Titolo: Mr. Nome: Pedro Cognome: Domingos Email: send email Telefono: +351 21 4469844 Fax: +351 21 4428766
Nazionalità Coordinatore	Portugal [PT]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IRG-2008
Funding Scheme	MC-IRG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-12-01   -   2014-04-01

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA  Organization address address: "Avenida da Republica, Estacao Agronomica Nacional" city: OEIRAS postcode: 2784-505 contact info Titolo: Mr. Nome: Pedro Cognome: Domingos Email: send email Telefono: +351 21 4469844 Fax: +351 21 4428766	PT (OEIRAS)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane proteins are synthesized and folded. The presence of unfolded/misfolded proteins in the ER causes stress to the cell (“ER stress”) and activates the Unfolded Protein Response (UPR), a cellular response to restore homeostasis in the ER. The presence of misfolded proteins and activation of the UPR have been connected with many diseases and pathological conditions. My goal is to elucidate the molecular mechanisms that regulate neuronal degeneration and cell death induced by ER strees, using Drosophila melanogaster as a model system. To achieve this goal, I propose the following specific aims: 1. Analysis of the molecular mechanisms required for induction of cell death in the context of ER stress. 2. The mechanism of induction of cell death by Xbp1spliced 3. Developmental role of the UPR during photoreceptor differentiation.'

Introduzione (Teaser)

Proteins that are not folded properly are connected with many diseases. An EU-funded project has investigated one such example, retinitis pigmentosa (RP), a major cause of blindness.