ENVIROGENOMARKERS
Genomics biomarkers of environmental health
| Coordinatore | ETHNIKO IDRYMA EREVNON
Organization address
address: Vassileos Constantinou Avenue 48 contact info |
| Nazionalità Coordinatore | Greece [EL] |
| Totale costo | 4˙858˙423 € |
| EC contributo | 3˙500˙000 € |
| Programma | FP7-ENVIRONMENT
Specific Programme "Cooperation": Environment (including Climate Change) |
| Code Call | FP7-ENV-2008-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-03-01 - 2013-02-28 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ETHNIKO IDRYMA EREVNON
Organization address
address: Vassileos Constantinou Avenue 48 contact info |
EL (ATHENS) | coordinator | 474˙174.40 |
| 2 |
UNIVERSITEIT MAASTRICHT
Organization address
address: Minderbroedersberg 4-6 contact info |
NL (MAASTRICHT) | participant | 643˙091.00 |
| 3 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
UK (LONDON) | participant | 437˙001.20 |
| 4 |
UNIVERSITEIT UTRECHT
Organization address
address: Heidelberglaan 8 contact info |
NL (UTRECHT) | participant | 417˙375.00 |
| 5 |
TERVEYDEN JA HYVINVOINNIN LAITOS
Organization address
address: MANNERHEIMINTIE 166 contact info |
FI (HELSINKI) | participant | 334˙257.60 |
| 6 |
UMEA UNIVERSITET
Organization address
address: UNIVERSITETOMRADET contact info |
SE (UMEA) | participant | 324˙900.00 |
| 7 |
PANEPISTIMIO KRITIS
Organization address
address: UNIVERSITY CAMPUS GALLOS contact info |
EL (RETHIMNO) | participant | 260˙000.40 |
| 8 |
ISTITUTO PER LO STUDIO E LA PREVENZIONE ONCOLOGICA
Organization address
address: VIA COSIMO IL VECCHIO 2 contact info |
IT (Florence) | participant | 235˙200.00 |
| 9 |
UNIVERSITY OF LEEDS
Organization address
address: WOODHOUSE LANE contact info |
UK (LEEDS) | participant | 204˙000.00 |
| 10 |
LUNDS UNIVERSITET
Organization address
address: Paradisgatan 5c contact info |
SE (LUND) | participant | 120˙000.00 |
| 11 |
ISTITUTO SUPERIORE DI SANITA
Organization address
address: Viale Regina Elena 299 contact info |
IT (ROMA) | participant | 50˙000.40 |
| 12 |
NATIONAL TAIWAN UNIVERSITY
Organization address
address: ROOSEVELT ROAD 1 contact info |
TW (TAIPEI) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'This project concerns the first large-scale application of the full range of –omics technologies in a population study aiming at a) the discovery and validation of novel biomarkers predictive of increased risks of a number of chronic diseases, b) the exploration of the association of such biomarkers with environmental exposures, including high-priority pollutants and emerging exposures, and c) the discovery and validation of biomarkers of exposure to the above and other high-priority environmental exposures. The project will utilise three existing prospective cohorts. Cancer-related -omics biomarkers will be developed using a case-control study nested within 2 cohorts which contain biosamples collected prior to disease diagnosis, exposure and followup health information. Biomarkers will be compared in 600 breast cancer cases, 300 NHL cases and equal numbers of matched controls, to evaluate their risk predictivity. Biomarkers of chronic diseases which establish themselves in early childhood but persist into adult life will be evaluated using a mother-child cohort. Biosamples collected from 600 children at birth and at ages 2 and 4 years will be analysed and results compared with clinical indices obtained at age 4. Thanks to the availability of repeat samples, collected over a wide range of time intervals, the intra-individual variation of biomarkers and their relationship with disease progression will be evaluated. Biomarker search will utilize state-of-the-art metabonomics, epigenomics, proteomics and transcriptomics, in combination with advanced bioinformatics and systems biology tools. It will also include technical validation of -omics technology’s utilisation with biobank samples. Exposure assessment will utilize exposure biomarkers, questionnaires, modelling and GIS technology. Additional data on exposure, biomarkers (including SNP data) and health indices, available through other projects, will be utilised, thus generating substantial added value.'
Introduzione (Teaser)
Environmental pollution can play a vital role in chronic diseases such as cancer as well as many neurological and immune diseases. European funding is helping to develop a new generation of biomarkers to study the effect of environmental agents in human disease.