COMBATING SEPSIS

WHY DO THEY DIE? DECIPHERING AND QUELLING THE LETHAL CUES OF IMMUNO-INFLAMMATORY RESPONSE IN SEPSIS

 Coordinatore LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG 

 Organization address address: NUSSDORFER STRASSE 64/6
city: WIEN
postcode: 1090

contact info
Titolo: Prof.
Nome: Soheyl
Cognome: Bahrami
Email: send email
Telefono: -33110426
Fax: -33110418

 Nazionalità Coordinatore Austria [AT]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-4-3-IRG
 Funding Scheme MC-IRG
 Anno di inizio 2007
 Periodo (anno-mese-giorno) 2007-12-01   -   2011-11-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG

 Organization address address: NUSSDORFER STRASSE 64/6
city: WIEN
postcode: 1090

contact info
Titolo: Prof.
Nome: Soheyl
Cognome: Bahrami
Email: send email
Telefono: -33110426
Fax: -33110418

AT (WIEN) coordinator 0.00

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 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

mortality    acute    expression    sepsis    gram    human    systemic    survival    lethal    therapy    peritonitis    outcome    immuno    upon    clp    inflammatory   

 Obiettivo del progetto (Objective)

'Sepsis is a multifaceted disease that remains a serious clinical problem and causes frequent mortality in human patients worldwide. The proposed project addresses the mechanisms and prevention of early mortality in experimental sepsis. To replicate human sepsis, murine models of live Escherichia coli and Streptococcus pyogenes systemic infusion and cecal ligation and puncture (CLP) peritonitis will be used. The project consists of three aims investigating acute immuno-inflammatory signaling triggered by a septic event: Aim I will study the role and modulation of differential genomic expression upon survival/mortality in gram-negative vs. gram-positive systemic sepsis. Based on the retrospective comparison of outcome in CLP sepsis, Aim II will differentiate between the non-lethal and lethal: (1)-gene/protein expression of inflammatory cytokines and (2)-changes in neurotransmitter fluctuations in different brain regions. Aim III will employ the novel strategy of prospective outcome-based stratification and investigate the effectiveness/mechanism of immuno-modulative anti-inflammatory therapy upon survival in mice predicted to die of acute CLP-induced polymicrobial peritonitis. There is an urgent need for treatments improving outcomes in sepsis and a rise of a new effective, individual patient-based therapy against sepsis is contingent upon exhaustive understanding of its immuno-inflammatory fingerprints. Successful accomplishment of the projected study will contribute to this effort.'

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