LOW-ENERGY ELECTRONS

"Experimental investigation of physico-chemical effects of low-energy electron interaction with isolated, clustered and self-assembled biomolecules"

 Coordinatore THE OPEN UNIVERSITY 

 Organization address address: WALTON HALL
city: MILTON KEYNES
postcode: MK7 6AA

contact info
Titolo: Prof.
Nome: Nigel
Cognome: Mason
Email: send email
Telefono: +44 (0) 1908 655132
Fax: +44 (0) 1908 654192

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-4-3-IRG
 Funding Scheme MC-IRG
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-03-01   -   2012-02-29

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE OPEN UNIVERSITY

 Organization address address: WALTON HALL
city: MILTON KEYNES
postcode: MK7 6AA

contact info
Titolo: Prof.
Nome: Nigel
Cognome: Mason
Email: send email
Telefono: +44 (0) 1908 655132
Fax: +44 (0) 1908 654192

UK (MILTON KEYNES) coordinator 0.00

Mappa


 Word cloud

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deposited    molecules    electron    amino    acids    structure    electronic    oligonucleotides    water    microscopy    energy    dna    performed    spectroscopy    lipid    electrons    interaction    radicals    substrate   

 Obiettivo del progetto (Objective)

'The proposed study will focus on effects of low-energy electron interaction with isolated amino acids and short peptides deposited on lipid bilayers mimicking the cellular membrane, as well as on oligonucleotides and on DNA. Owing to the simple structure of phospholipids, they present a geometrically and physico-chemically well-defined biomolecular array and potentially an ideal matrix for homogenous distribution of amino-acids, nucleotides, DNA, and RNA chains, with or without presence of water. By finding the probability for the temporary electron attachment to amino acids, oligonucleotides and DNA molecules and observing and quantifying the effects of vibrational and/or electronic excitation when molecules are combined into more complex structure, the proposed research will be advancing the knowledge in Physics, Chemistry and Biology and will be relevant for nanotechnology in their quest for new materials and creation of electronic molecular devices. The analysis of damage products (radicals) from the interaction of electrons and ion radicals with short oligonucleotides and DNA deposited on lipid films in the presence of specific amino acids will be performed aiming to possibly tracking the path of proton transfer and oxygen radical in the substrate after irradiation by electrons. An important aspect of the proposed research is investigation of the role of water in the processes of resonance formation and fragmentation of lipids and other biomolecules deposited on a lipid substrate. Measurements will be performed using several experimental techniques: Electron Energy Loss spectroscopy (Time-of-Flight measurements of the spatial and temporal distribution of electrons reflected from the sample and transmitted current measurements), X-ray Photoelectron Spectroscopy (using micro-beams; synchrotron installation), High Performance Liquid Chromatography, and gel electrophoreses. Atomic Force Microscopy and Scanning Tunneling Microscopy images will be used in addition.'

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