TRANSLATION CONTROL

Regulation of selective translation via signal transduction pathways

 Coordinatore Novartis Forschungsstiftung 

 Organization address address: Maulbeerstrasse 66
city: BASEL
postcode: 4058

contact info
Titolo: Ms.
Nome: Dorothy
Cognome: Searles
Email: send email
Telefono: -6973002
Fax: -6973996

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 0 €
 EC contributo 190˙864 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IEF-2008
 Funding Scheme MC-IEF
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-03-01   -   2011-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Novartis Forschungsstiftung

 Organization address address: Maulbeerstrasse 66
city: BASEL
postcode: 4058

contact info
Titolo: Ms.
Nome: Dorothy
Cognome: Searles
Email: send email
Telefono: -6973002
Fax: -6973996

CH (BASEL) coordinator 190˙864.30

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cell    selective    translation    molecular    modes    expression    mechanisms    addition    human    translational    machinery    regulate    pathways    biology    signalling    phosphorylation    complexes   

 Obiettivo del progetto (Objective)

'The overall rate of protein synthesis is an important factor modulating cell and tissue metabolism. In addition, the translational machinery plays key roles in controlling gene-specific expression in eukaryotic cells. The regulatory mechanisms involve changes in the activities of components of translational complexes that lead to selective translation of specific subsets of messenger RNAs. Modulations of translational activity are primarily mediated by changes in the phosphorylation states of translation factors or RNA-binding proteins promoting specific modes of translation. Kinases closely associated with translation initiation complexes have a huge potential to regulate selective modes of translation. However, despite many studies on signalling pathways controlling the phosphorylation status of the translation machinery, little is known about how these modifications regulate the quality of the translation. The main research objective is to uncover novel molecular mechanisms regulating the expression of specific genes at the translation level triggered by signalling pathways. The project proposed will make use of a variety of modern molecular biology, biochemistry and cell biology techniques, including detailed proteomic and genomic analyses. In addition, the clinical relevance of the new identified mechanism will be analysed in human brain cancer. Understanding the mechanisms selecting specific mRNAs for translation would not only explain the principles underlying rapid signalling responses controlling translation and the phenotypical consequences but would also allow development of molecular strategies for therapeutic interference in human diseases with deregulated signalling pathways.'

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