MODEL OF IMPULSIVITY

Characterization of a rodent model of impulsivity with implications for drug addiction

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Edna Cognome: Murphy Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	0 €
EC contributo	171˙867 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-06-01   -   2011-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Edna Cognome: Murphy Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	coordinator	171˙867.62

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 Obiettivo del progetto (Objective)

'As a chronically relapsing brain disorder drug addiction places a major social and economic burden on society, not least on crime rate and health care provision. It is increasingly accepted that drug addiction results from complex interactions between pre-disposing behavioural variables or traits (e.g., sensation-seeking, impulsiveness), chronic drug exposure and environmental influences including learning experiences. Recently, ‘trait-like’ impulsivity in rats has been reported to be highly predictive of the development of compulsive (or habitual) cocaine-seeking behaviour that persists despite adverse consequences, a hallmark feature of addiction (Dalley et al., 2007; Belin et al., 2008). The proposed research aims to investigate the hypothesis that impulsive rats are more prone to habit-based behaviour than non-impulsive rats, a propensity postulated to depend on the prefrontal cortex (PFC) and impaired processing of contextual (environmental) attributes by the PFC and associated brain regions. The central objective of this research is to better understand the interaction between individual differences in impulsivity and contextual learning experiences and how this interaction facilitates the transition to habitual or compulsive patterns of drug-seeking. Specifically, this research will compare impulsive rats and non-impulsive rats in their sensitivity to outcome devaluation (OD), a test of habit-based learning and the role of the context in this process. This research will also investigate the role of PFC DA in the modulation of context-dependent OD by administering DA as well as selective DA receptor agonists and antagonists directly into the PFC of impulsive and non-impulsive rats. Overall, this research project integrates behavioural theories of learning (Bouton, 2002) with state-of-the-art drug addiction hypothesises (Everitt & Robbins, 2005) to elucidate how innate and environmental factors play a role in maladaptive behaviours relevant to drug addiction.'