MD-THIV

Migration and Differentiation of Th17 Cells in HIV/SIV Infection

 Coordinatore FONDAZIONE PER L'ISTITUTO DI RICERC A IN BIOMEDICINA 

 Organization address address: Via Vincenzo Vela 6
city: BELLINZONA
postcode: 6500

contact info
Titolo: Dr.
Nome: Mariagrazia
Cognome: Uguccioni
Email: send email
Telefono: 41918200316
Fax: 41918200305

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 180˙801 €
 EC contributo 180˙801 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IEF-2008
 Funding Scheme MC-IEF
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-06-01   -   2012-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FONDAZIONE PER L'ISTITUTO DI RICERC A IN BIOMEDICINA

 Organization address address: Via Vincenzo Vela 6
city: BELLINZONA
postcode: 6500

contact info
Titolo: Dr.
Nome: Mariagrazia
Cognome: Uguccioni
Email: send email
Telefono: 41918200316
Fax: 41918200305

CH (BELLINZONA) coordinator 180˙801.44

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

infection    pathogenesis    disease    decrease    trafficking    cd    frequency    mechanisms    hiv    progression    alterations    virus    aids    siv    loss    macaques    immunodeficiency    cells    immune   

 Obiettivo del progetto (Objective)

'More than 25 years after the discovery of human immunodeficiency virus (HIV) as the causative agent of AIDS, the mechanisms governing pathogenesis and disease progression are still not fully understood. Indeed, a progressive impairment of the immune system, with alterations that affect both innate and adaptive immunity, characterizes the infection with HIV 1 in humans and with simian immunodeficiency virus (SIV) in macaques. It has been proposed that a state of chronic immune activation contributes to loss of CD4 T cells and to alterations of immune responses, ultimately leading to disease progression. The loss of CD4CCR5 T cells in the gut associated lymphoid tissue (GALT) has been well documented both in natural host and in pathogenic models of SIV infection. A decrease in the frequency of Th17 cells, a newly discovered subset of effector T cells involved in the immune response against extracellular bacteria, has been recently described by the applicant, in the mucosa of SIV infected rhesus macaques. Nevertheless the migratory capacity of this T cell subpopulation has not been investigated so far. Chemokines are important mediators of leukocyte trafficking and function, and deregulation of their expression might contribute in part to the pathogenesis of HIV-1/SIV infection. The aim of this project is to investigate the mechanisms that mediate Th17 cells trafficking and activities at mucosal sites together with their decrease in frequency during HIV/SIV infection in order to better understand the pathogenesis of AIDS, in view of generating efficient vaccines.'

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