Coordinatore | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address
address: BATIMENT CE 3316 STATION 1 contact info |
Nazionalità Coordinatore | Switzerland [CH] |
Totale costo | 180˙801 € |
EC contributo | 180˙801 € |
Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
Code Call | FP7-PEOPLE-IEF-2008 |
Funding Scheme | MC-IEF |
Anno di inizio | 2009 |
Periodo (anno-mese-giorno) | 2009-05-01 - 2009-06-30 |
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1 |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address
address: BATIMENT CE 3316 STATION 1 contact info |
CH (LAUSANNE) | coordinator | 180˙801.44 |
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'The overall objective of this proposal is to determine the effect of specific disease associated post-translational modifications, more specifically phosphorylation and nitration, on modulating the structural and biochemical properties of a-synuclein. In detail, we plan to assess the effect of these modifications on i) the structure of monomeric and membrane bound a-synuclein; ii) the oliogmerization and fibrillogenesis of a-syn; iii) subcellular localization and targeting of a-syn to specific cellular compartments. Towards this goal, we plan to use a combination of chemical biology and semisynthetic strategies to 1) synthesize a-syn variants that are modified at specific sites 2) make use of caged amino acids and fluorescent tags to allow temporal and spatial induction and control of post-translational modification in living cells.'
"Complex Research of Earthquake’s Prediction Possibilities, Seismicity and Climate Change Correlations"
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