INTRA PATH

Molecular Characterisation of the INTRAcellular Plant Aquaporin Trafficking and Hetero-oligomerisation

 Coordinatore UNIVERSITE CATHOLIQUE DE LOUVAIN 

 Organization address address: Place De L'Universite 1
city: LOUVAIN LA NEUVE
postcode: 1348

contact info
Titolo: Prof.
Nome: François
Cognome: Chaumont
Email: send email
Telefono: -478463
Fax: -473850

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 0 €
 EC contributo 158˙989 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IEF-2008
 Funding Scheme MC-IEF
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-04-01   -   2011-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN

 Organization address address: Place De L'Universite 1
city: LOUVAIN LA NEUVE
postcode: 1348

contact info
Titolo: Prof.
Nome: François
Cognome: Chaumont
Email: send email
Telefono: -478463
Fax: -473850

BE (LOUVAIN LA NEUVE) coordinator 158˙989.69

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

generate    interaction    plasma    aquaporins    pip    hetero    responsible    pm    protein    aqp    trafficking    water    mechanisms    redistribution    transport    plant       aqps    functions    plants    membrane   

 Obiettivo del progetto (Objective)

'In plants, the movement of water and small neutral solutes across the plasma membrane (PM) is dependent on the number and activity of water channels, named aquaporins (AQP). Little is known about mechanisms by which AQPs reach their final destination. Recent studies have shown that PIP (Plasma membrane Intrinsic Protein) aquaporins belonging to two subgroups, PIP1 and PIP2, physically interact to regulate their trafficking and the cell membrane water permeability. Therefore, this mechanism might play a pivotal role for the regulation of PIP functions. The main objective of the project is to generate detailed knowledge about the mechanisms regulating the intracellular trafficking of PIP1 and PIP2 aquaporins and the implication of their mutual interaction. To achieve this goal, 4 work packages have been defined. 1) We will characterise protein motifs responsible for ER retention of PIP1s and PM trafficking of PIP2s. 2) The amino acid residues responsible for the physical interaction between PIP1 and PIP2 isoforms will be determined. 3) We will investigate the transport capacity and selectivity of PIP hetero-oligomers. 4) Mechanisms governing subcellular PIP redistribution and dynamics upon specific stimuli will be characterised. The project represents a fundamental scientific approach providing valuable insights into hetero-oligomer formation, sorting and spatial redistribution of PIPs and will clearly advance the “state of the art” of the plant AQP research. It will generate a highly relevant basis for the uncovering of specific AQP functions in cells, tissues and thus in the metabolism of plants. Furthermore, these data will be crucial for the use of AQPs in biotechnological or plant breeding strategies aiming at a modulated water or solute transport leading to a higher drought resistance or an improved nutrient uptake or distribution in plants. Such traits demand a precise localisation of AQPs rather than a spatially uncontrolled modulation of AQP expression.'

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