SUPRASYMCAT
Supramolecular Modular Approaches to Asymmetric Catalysis: Synthesis of Ligands by a Metal-Ligand Mediated Assembly Process
| Coordinatore | FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
Organization address
address: AVINGUDA PAISOS CATALANS 16 contact info |
| Nazionalità Coordinatore | Spain [ES] |
| Totale costo | 151˙936 € |
| EC contributo | 151˙936 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2007-4-2-IIF |
| Funding Scheme | MC-IIF |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-06-09 - 2011-06-08 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
Organization address
address: AVINGUDA PAISOS CATALANS 16 contact info |
ES (TARRAGONA) | coordinator | 0.00 |
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Obiettivo del progetto (Objective)
'Catalysis has been one of the longstanding proposed applications of supramolecular chemistry, which has reached a level of development that allows the practitioner to achieve the design and construction of complex multicomponent assemblies with exquisite detail. Efficient supramolecular systems capable of recognition and catalysis have emerged in recent years, however, the application of supramolecular interactions to generate chiral catalysts is still in its infancy, and reports in the literature are scarce. Our approach focuses on the generation of chiral ligands capable of exploiting supramolecular interactions, and is based on a self-assembly process between the chiral and catalytic components. During the self-assembly process, the chiral information will be transferred from the chiral unit to the catalytic unit and a new supramolecular entity will be formed which will assume the role of the ligand in the asymmetric transformation. The main advantage of this approach rests on the ability to modify the geometry of the catalytic site through non-covalent interactions (hydrogen- and metal-ligand bonding): this geometry will be influenced by the three-dimensional structure of the chiral fragment which is used. Due to the great diversity of possible chiral units, the reactive centre will be able to adopt a range of geometries created by systematic modification of this unit. Our strategy can be easily parallelised to rapidly generate ligand libraries, in which the ligands will preserve most the structural generalities of their predecessors, but it will incorporate “subtle” changes in their three-dimensional structure that will improve the catalytic properties of the assemblies.'
Introduzione (Teaser)
Much as the computer has revolutionised the speed at which we can perform complex calculations, biochemical catalysts enhance the rate at which reactions proceed. EU researchers have developed new methods to further enhance the activity of specific catalytic systems, with implications for many industrial processes.