HEARTREGENERATION

Transplantation of magnetic-labelled vascular cells and cardiomyocytes isolated from human embryonic stem cells in a bioactive injectable gel for myocardium regeneration after infarct

Coordinatore	CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO    more  Organization address address: UNIVERSIDADE DE COIMBRA . city: COIMBRA postcode: 3004 517 contact info Titolo: Dr. Nome: Euclides Cognome: Pires Email: send email Telefono: 351240000000 Fax: 351240000000
Nazionalità Coordinatore	Portugal [PT]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IRG-2008
Funding Scheme	MC-IRG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-04-01   -   2013-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO  Organization address address: UNIVERSIDADE DE COIMBRA . city: COIMBRA postcode: 3004 517 contact info Titolo: Dr. Nome: Euclides Cognome: Pires Email: send email Telefono: 351240000000 Fax: 351240000000	PT (COIMBRA)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Cardiovascular diseases remain the number one cause of death in the western world. Human embryonic stem cells (hESCs) represent a promising source of cells for the treatment of cardiovascular diseases because of their unlimited cell propagation and ability to give rise to different cell types, including cardiomyocytes, endothelial and smooth muscle cells. Cardiomyocytes isolated from hESCs have been shown to form new myocardium after infarct; however, the functional recovery of the myocardium was low and the functional coupling was inexistent since the cardiomyocytes were observed within the scar and not in direct contact with host cardiomyocytes (Laflamme et al., Nat Biotechnol 2007). So far, no studies have reported the benefits of prevascularizing cardiomyocyte cell constructs to enhance in vivo cell viability, grafting and functional coupling. Additionally, we anticipate that the transplantation of these cells using an injectable bioactive gel will enhance cell retention and viability at the injection site. This projects aims at evaluating the neovascularization and myocardium functional recovery after transplanting hESC-derived cardiomyocytes and vascular cells into a myocardial infarction animal model. Recently, we isolated endothelial and smooth muscle cells from hESCs that form microvessels when injected subcutaneously in nude mice and thus might be an important cell source for the vascularization of the myocardium. In addition, this projects aims at developing a bioactive injectable gel to function as a temporary three-dimensional scaffold and a protocol to monitor non-invasively in vivo cell grafting.'