HEARTREGENERATION

Transplantation of magnetic-labelled vascular cells and cardiomyocytes isolated from human embryonic stem cells in a bioactive injectable gel for myocardium regeneration after infarct

 Coordinatore CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO 

 Organization address address: UNIVERSIDADE DE COIMBRA .
city: COIMBRA
postcode: 3004 517

contact info
Titolo: Dr.
Nome: Euclides
Cognome: Pires
Email: send email
Telefono: 351240000000
Fax: 351240000000

 Nazionalità Coordinatore Portugal [PT]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IRG-2008
 Funding Scheme MC-IRG
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-04-01   -   2013-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

 Organization address address: UNIVERSIDADE DE COIMBRA .
city: COIMBRA
postcode: 3004 517

contact info
Titolo: Dr.
Nome: Euclides
Cognome: Pires
Email: send email
Telefono: 351240000000
Fax: 351240000000

PT (COIMBRA) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cells    cell    myocardium    functional    gel    muscle    bioactive    recovery    hescs    isolated    coupling    endothelial    cardiovascular    viability    smooth    diseases    source    cardiomyocytes    injectable    grafting    vivo    form   

 Obiettivo del progetto (Objective)

'Cardiovascular diseases remain the number one cause of death in the western world. Human embryonic stem cells (hESCs) represent a promising source of cells for the treatment of cardiovascular diseases because of their unlimited cell propagation and ability to give rise to different cell types, including cardiomyocytes, endothelial and smooth muscle cells. Cardiomyocytes isolated from hESCs have been shown to form new myocardium after infarct; however, the functional recovery of the myocardium was low and the functional coupling was inexistent since the cardiomyocytes were observed within the scar and not in direct contact with host cardiomyocytes (Laflamme et al., Nat Biotechnol 2007). So far, no studies have reported the benefits of prevascularizing cardiomyocyte cell constructs to enhance in vivo cell viability, grafting and functional coupling. Additionally, we anticipate that the transplantation of these cells using an injectable bioactive gel will enhance cell retention and viability at the injection site. This projects aims at evaluating the neovascularization and myocardium functional recovery after transplanting hESC-derived cardiomyocytes and vascular cells into a myocardial infarction animal model. Recently, we isolated endothelial and smooth muscle cells from hESCs that form microvessels when injected subcutaneously in nude mice and thus might be an important cell source for the vascularization of the myocardium. In addition, this projects aims at developing a bioactive injectable gel to function as a temporary three-dimensional scaffold and a protocol to monitor non-invasively in vivo cell grafting.'

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