MAPBYADMIXTURECHL

Mapping Genes involved in Psychiatric Disorders by Admixture Linkage Disequilibrium in Chilean populations

 Coordinatore UNIVERSIDAD POMPEU FABRA 

 Organization address address: PLACA DE LA MERCE 10-12
city: BARCELONA
postcode: 8002

contact info
Titolo: Dr.
Nome: David
Cognome: Comas
Email: send email
Telefono: +34 933160843
Fax: +34 933160901

 Nazionalità Coordinatore Spain [ES]
 Totale costo 272˙968 €
 EC contributo 272˙968 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IOF-2008
 Funding Scheme MC-IOF
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-08-01   -   2012-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSIDAD POMPEU FABRA

 Organization address address: PLACA DE LA MERCE 10-12
city: BARCELONA
postcode: 8002

contact info
Titolo: Dr.
Nome: David
Cognome: Comas
Email: send email
Telefono: +34 933160843
Fax: +34 933160901

ES (BARCELONA) coordinator 272˙968.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

psychiatric    susceptibility    hyperactivity    replication    genes    powerful    map    admixture    american    disequilibrium    genetic    variants    existence    mald    association    chile    linkage    disorders    native    disease    populations    deficit   

 Obiettivo del progetto (Objective)

'Psychiatric disorders show a complex pattern of inheritance with genetic and environmental factors influencing disease risk. Despite the existence of numerous association studies aiming to identify genetic variants involved in these disorders, inconsistencies in replication studies are common and just a few examples of links between gene variants and psychiatric disorders have been accepted. Several factors may be underlying the failure on replication: difficulties on the definition of clinical phenotypes, existence of distinct disease incidences or disease susceptibility variants among populations and, finally, differences in Linkage Disequilibrium and allele frequencies because of diverse population history. Whole genome association studies (WGAS) are powerful methods to map disease genes, however, these expensive techniques have been unsuccessful for psychiatric disorders. An alternative approach could be the use of mapping by admixture linkage disequilibrium (MALD), an efficient and economical method to localize disease-causing variants between two historically separated populations. MALD has already been successful for identification of disease loci in African American populations and, similarly, it is hoped to be a powerful tool in Latin American populations. We propose the design of an admixture panel of SNPs to map susceptibility genes for psychiatric disorders, particularly substance use and attention-deficit hyperactivity disorders, by the analysis of native (Aymara) and recently admixed populations from Chile. Furthermore, we also plan to assess the repercussions that different genetic structures among populations may have on the interpretation of association studies and, finally, we will search for signals of natural selection and adaptation pinpointing potential genes affecting behavioural traits. This collaborative and interdisciplinary project will also focus on the anthropological and cultural implications of the research and results obtained.'

Introduzione (Teaser)

European funded research has taken the technique of admixture linkage disequilibrium to Chile for the study of attention-deficit hyperactivity disorder (ADHD) in native populations.

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