NUCLEOPOLY

DNA Block Copolymers: New Architectures and Applications

Coordinatore	RIJKSUNIVERSITEIT GRONINGEN    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	1˙500˙000 €
EC contributo	1˙500˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2009-StG
Funding Scheme	ERC-SG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-11-01   -   2014-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	RIJKSUNIVERSITEIT GRONINGEN  Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP contact info Titolo: Dr. Nome: H.D. Cognome: Veldhuis Email: send email Telefono: +31 50 363 4142 Fax: +31 50 363 4500	NL (GRONINGEN)	hostInstitution	1˙500˙000.00
2	RIJKSUNIVERSITEIT GRONINGEN  Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP contact info Titolo: Prof. Nome: Andreas Cognome: Herrmann Email: send email Telefono: 31503636318 Fax: 31503634400	NL (GRONINGEN)	hostInstitution	1˙500˙000.00

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 Obiettivo del progetto (Objective)

'With our contributions to DNA block copolymers (DBCs), we have opened a new field of interdisciplinary research at the intersection of polymer chemistry, biology and nanoscience. Within this proposal, we intend to apply our expertise with linear DBCs to new nucleocopolymer architectures ranging from star polymers to DNA networks. Our efforts will not only explore new covalently-bonded polymer topologies but also extend the range of self-assembled supramolecular structures accessible with DBCs. Current progress in this direction has yielded spherical and rod-like DBC micelles. In this proposal we further envisage membranes and vesicles generated by macromolecular DNA amphiphiles. A special focus will be the manipulation of the permeability of these structures by hybridization and the insertion of channel proteins. A major part of the proposal addresses potential applications of DBC architectures in the fields of nucleic acid detection and drug delivery. We will produce selective and sensitive nucleic acid probes employing DBCs with highly emissive conjugated polymer segments or based on novel fluorogenic DNA-templated reactions. Plans for potential delivery systems include the establishment of a DBC-based technology platform to allow combinatorial testing of micelle structures equipped with improved targeting, drug loading and stealth functions. For this purpose, the DNA shell of the nanoscopic aggregates will be exploited for its biological activity in the context of antisense and small interfering RNA activity as well as immune stimulation. Finally, we will employ DBC micelles as programmable nanoreactors within the complex environment of living cells and even carry out sequence-specific organic transformations induced by the cell s own messenger RNA'