NANOHEDONISM

A Photo-triggered On-demand Drug Delivery System for Chronic Pain

Coordinatore	UNIVERSIDAD DE ZARAGOZA    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Spain [ES]
Totale costo	1˙570˙091 €
EC contributo	1˙570˙091 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-CoG
Funding Scheme	ERC-CG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-03-01   -   2019-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSIDAD DE ZARAGOZA  Organization address address: CALLE PEDRO CERBUNA 12 city: Zaragoza postcode: 50009 contact info Titolo: Dr. Nome: Manuel Cognome: Arruebo Gordo Email: send email Telefono: +34 876555437 Fax: +34 976761879	ES (Zaragoza)	hostInstitution	1˙570˙091.00
2	UNIVERSIDAD DE ZARAGOZA  Organization address address: CALLE PEDRO CERBUNA 12 city: Zaragoza postcode: 50009 contact info Titolo: Ms. Nome: Carmen Cognome: Baras Email: send email Telefono: +34 876 553 109 Fax: +34 976 76 10 48	ES (Zaragoza)	hostInstitution	1˙570˙091.00

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 Obiettivo del progetto (Objective)

'Nerve pain affects millions of people, and can be personally devastating for people who experience it. Current methods for pain management (e.g. local injection of pain killers) are inadequate because of the short duration of action. Even sustained release treatments, such as drug-loaded liposomes, provide only one week of analgesia producing a continuous extended nerve blockade without allowing for changes in daily physical activity or level of pain relief. More importantly, such systems cannot be turned off until they run their course.

In this proposal, a locally-injected or implanted near infrared (NIR)-sensitive drug reservoir that can be triggered by a simple handheld laser device applied externally is described. The device enables drug release with consistent response over multiple on/off cycles. Such a device, implanted (or eventually injected) on a nerve or near the neuraxis, could have substantial clinical impact in the treatment of chronic (or prolonged perioperative) pain.

This system will consist of an impermeable ethylcellulose membrane embedded with temperature-sensitive polymer nanoparticles and NIR-active gold nanoparticles. The membrane will be engineered such that the nanoparticles form a disordered but interconnected network throughout. The gold nanoparticle concentration will be adjusted so that light-induced heating of the nanoparticles produces sufficient heat to collapse the polymer, thus opening the porous network. Those nanostructured materials which compose the device will be produced in a continuous manner by using microfluidic reactors to avoid the characteristic disadvantages when using conventional discontinuous (batch) reactors. Nanoparticle-synthesis protocols will be supported by computational fluid dynamics.

The specific aims will be geared toward engineering a NIR-triggered drug release device and optimizing for a variety of drug types, then demonstrating its biocompatibility and therapeutic effectiveness in vivo.'