BMDCS IN CANCER

The impact of bone-marrow derived cells on tumor growth and metastasis after cytotoxic anti-cancer drug treatment

 Coordinatore TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY 

 Organization address address: TECHNION CITY - SENATE BUILDING
city: HAIFA
postcode: 32000

contact info
Titolo: Mr.
Nome: Mark
Cognome: Davison
Email: send email
Telefono: +972 4 829 4854
Fax: +972 4 823 2958

 Nazionalità Coordinatore Israel [IL]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IRG-2008
 Funding Scheme MC-IRG
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-04-01   -   2013-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

 Organization address address: TECHNION CITY - SENATE BUILDING
city: HAIFA
postcode: 32000

contact info
Titolo: Mr.
Nome: Mark
Cognome: Davison
Email: send email
Telefono: +972 4 829 4854
Fax: +972 4 823 2958

IL (HAIFA) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

vessel    cytotoxic    tumor    blood    lumen    cells    types    bmdc    cell    treatment    marrow    angiogenesis    contribution    bone    capillaries    metastasis    drugs    inhibit    ceps    host    cancer    drug    tumors   

 Obiettivo del progetto (Objective)

'One of the more important recent developments in clinical oncology has been the approval of antiangiogenic drugs for the treatment of various types of cancer. We have found that these drugs not only act locally to inhibit the formation of new blood vessel capillaries in tumors, but also systemically by targeting bone marrow-derived endothelial precursor cells (CEPs). It has been suggested that other bone marrow-derived cell (BMDC) types contribute to tumor angiogenesis and growth by either directly incorporating to the vessel lumen or by residing at preivascular site - promoting angiogenesis by unknown paracrine mechanisms. With respect to CEPs, there is an ongoing controversy about their relative contribution to tumor blood vessel formation, in large due to a number of studies which reported low or even no detectable incorporation of such cells to the lumen of tumor blood vessel capillaries. We have recently shown that there are circumstances, namely, after acute cytotoxic drug therapy using vascular disrupting agents, or chemotherapy drugs including pactliaxel, 5-flourouracil, and docetaxel, where levels of CEPs are acutely mobilized from the bone-marrow niche, and subsequently colonize the drug-treated tumors, where they can make a significant contribution to tumor re-growth. These observations suggest a new perspective as for the role of CEPs in tumor angiogenesis and growth. Here, we propose to evaluate the contribution of different BMDC types to tumor angiogenesis and growth, and their contribution to metastasis seeding after treatment with cytotoxic anti-cancer drug therapies. In addition we will identify the various host factors and cytokines which promote BMDC mobilization and tumor homing. A major emphasis will be placed on new treatment strategies that can inhibit the host bone-marrow responses which contribute to tumor cell repopulation and metastasis, and as such the results could reveal new combinatorial promising treatment modalities for cancer.'

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