DOPAMINE

The role of the dopamine system in human reinforcement learning

Coordinatore	UNIVERSITEIT LEIDEN    more  Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2300 RA contact info Titolo: Dr. Nome: Menno Cognome: Tuurenhout Email: send email Telefono: -5274095 Fax: -5273659
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	30˙000 €
EC contributo	30˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-ERG-2008
Funding Scheme	MC-ERG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-08-01   -   2011-11-21

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT LEIDEN  Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2300 RA contact info Titolo: Dr. Nome: Menno Cognome: Tuurenhout Email: send email Telefono: -5274095 Fax: -5273659	NL (LEIDEN)	coordinator	30˙000.00

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 Obiettivo del progetto (Objective)

'Animal research has indicated an important role for the ventral tegmental area (VTA) and its neurotransmitter dopamine in reinforcement learning, an elementary form of learning on the basis of rewards and punishments. In recent years, cognitive neuroscientists have used these animal data to develop various highly sophisticated theories on the role of the dopamine system in human reinforcement learning. However, crucial empirical tests of these theories in human subjects have generally been lacking, probably in part because of the considerable methodological challenges involved. The goal of the proposed research program is to address these challenges using a number of novel methods: (i) High-field (7 Tesla) functional magnetic resonance imaging in combination with a set of recently published acquisition and analysis methods will allow us to directly measure activity of the VTA; and (ii) pharmacological magnetic resonance imaging will allow us to investigate the effects of experimental manipulations of the dopamine system on brain function and behavior. We will use these methods to test detailed theoretical predictions regarding the role of the human dopamine system in coding error responses and negative feedback, in learning from positive and negative outcomes, and in valuing immediate versus delayed rewards. The proposed research will be important in elucidating the role of the dopamine system in human reinforcement learning. At the methodological level, it will open the door for the careful study of the role of dopamine in human cognition at large.'