MODELLING_JOINT_DEV

Modelling Joint Development: Integrating Biological and Mechanical Influences

 Coordinatore FUNDACIO CENTRE DE REGULACIO GENOMICA 

 Organization address address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003

contact info
Titolo: Mr.
Nome: Stefan
Cognome: Pönisch
Email: send email
Telefono: +349 33160264
Fax: +349 33969983

 Nazionalità Coordinatore Spain [ES]
 Totale costo 153˙535 €
 EC contributo 153˙535 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IEF-2008
 Funding Scheme MC-IEF
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-11-01   -   2011-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FUNDACIO CENTRE DE REGULACIO GENOMICA

 Organization address address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003

contact info
Titolo: Mr.
Nome: Stefan
Cognome: Pönisch
Email: send email
Telefono: +349 33160264
Fax: +349 33969983

ES (BARCELONA) coordinator 153˙535.05

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

interzone    mechanical    form    embryonic    morphogenesis    become    simulation    forces    cavitation    model    me    tissue    cavity    stages    surfaces    joint    cartilage    articular    synovial   

 Obiettivo del progetto (Objective)

'Embryonic joint development is a complex process with several distinct stages. The first step occurs in the cartilage anlage, where chondrocytes at the presumptive joint site stop proliferating and become compacted to form what is called the interzone. From the interzone, the synovial cavity develops. Once the cavity has been initiated, the surfaces of the opposing cartilage rudiments undergo gradual shape morphogenesis so that the ends of the two bones form a functioning, friction-minimising contact surface, i.e., a synovial joint. It has been shown that mechanical forces are essential for normal cavitation of the joint, while it is not yet clear whether mechanical forces are an essential influence for moulding of the articular surfaces. If embryos are immobilised prior to cavitation, the process does not occur, while if immobilisation is induced after the cavity has formed, the cavity regresses and the elements can become fused. In this application, I propose a computational simulation of joint development, modelling cavitation of the joint and morphogenesis of the articular surfaces based on the interactions between mechanical and biological factors. The aims of the project are to 1) characterise the developing joint in 3-D in the embryonic chick; 2) calculate the forces and biophysical stimuli active in the joint over several stages; 3) create 2-D model of simple joint, 4) alter mechanical state to corroborate model predictions; 5) investigate mechanosensitive molecules and genes, and 6) upgrade model to 3-D. Such a simulation will lead to a better understanding of joint development which would have significant consequences for medical applications such as osteoarthritis and tissue engineering. This project will enable me to become an expert at the interface between developmental biology and bioengineering, and equip me to become a successful researcher and principal investigator as a specialist in the mechanobiology of the developing limb.'

Introduzione (Teaser)

EU-funded researchers have provided experimental evidence for the role of mechanical forces in joint formation during embryonic development. Treatment of osteoporosis and tissue regeneration will benefit from these advances.

Altri progetti dello stesso programma (FP7-PEOPLE)

REVERSIBLE COGNITION (2012)

Prefrontal and cingulate interactions in cognitive control: reversible inactivation and electrocorticograms

Read More  

AXON REGENERATION (2010)

Regeneration and Target Reinnervation after Spinal Cord Injury

Read More  

JET X SECTION (2010)

Measurement of the inclusive jet cross section

Read More