DECODE

Decoding the complexity of quantitative natural variation in Arabidopsis thaliana

 Coordinatore INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE 

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 Nazionalità Coordinatore France [FR]
 Totale costo 1˙742˙113 €
 EC contributo 1˙742˙113 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-StG
 Funding Scheme ERC-SG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-02-01   -   2016-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

 Organization address address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338

contact info
Titolo: Dr.
Nome: Olivier
Cognome: Loudet
Email: send email
Telefono: -130833283
Fax: -130833286

FR (PARIS CEDEX 07) hostInstitution 1˙742˙113.00
2    INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

 Organization address address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338

contact info
Titolo: Ms.
Nome: Magali
Cognome: Nawrocki
Email: send email
Telefono: +33 1 30833282

FR (PARIS CEDEX 07) hostInstitution 1˙742˙113.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

quantitative    phenotyping    resolve    variation    source    qtls    gene    regulation    cis    molecular    genetics    natural    genetic    trait    significant   

 Obiettivo del progetto (Objective)

'Following a long history of quantitative genetics in crop plants, it now becomes feasible to use naturally-occuring variation contained in Arabidopsis thaliana accessions (lines isolated from natural populations) as the source of quantitative genomics approaches, designed to map QTLs and resolve them at the gene level. Apart from being able to exploit in multiple genetic backgrounds allelic variation that cannot be easily generated by conventional mutagenesis, the (relatively few) success of the QTL studies has often been because of the use of quantitative phenotyping, as opposed to the qualitative gauges used in typical mutant screens. Among the various genetic mechanisms responsible for natural variation that have just started to be revealed, cis-acting regulation is potentially of large impact, despite remaining more difficult to recognize and confirm. The objective of this project is to apply genome-wide quantitative molecular genetics to both, a very integrative and classical quantitative trait (growth in interaction with the environment) and a molecular trait a priori more directly linked to the source of variation (gene expression under cis-regulation). We propose to use a combination of our unique high-troughput phenotyping robot, fine-mapping, complementation approaches and association genetics to pinpoint a significant number of QTLs and eQTLs to the gene level and identify causative polymorphisms and the molecular variation controlling natural diversity. Working at an unprecedented scale should finally allow to resolve enough quantitative loci and pay a significant contribution to drawing a general picture as to how and where in the pathways adaptation is shaping natural variation and improve our understanding of the transcriptional cis-regulatory code.'

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