SCHISTOSOMA PROTEASE

BIOACTIVE SERINE PROTEASES FROM HUMAN PARASITE SCHISTOSOMA MANSONI

Coordinatore	USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE    more  Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 142 20 contact info Titolo: Dr. Nome: Sarka Cognome: Takacova Email: send email Telefono: 420241000000 Fax: 420224000000
Nazionalità Coordinatore	Czech Republic [CZ]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-RG
Funding Scheme	MC-IRG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-11-01   -   2013-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE  Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 142 20 contact info Titolo: Dr. Nome: Sarka Cognome: Takacova Email: send email Telefono: 420241000000 Fax: 420224000000	CZ (PRAHA 4)	coordinator	64˙583.33
2	"Biologicke centrum AV CR, v. v. i."  Organization address address: Branisovska 31 city: CESKE BUDEJOVICE postcode: 370 05 contact info Titolo: Prof. Nome: Tomáš Cognome: Scholz Email: send email Telefono: +420 387 775 403 Fax: +420 385310388	CZ (CESKE BUDEJOVICE)	participant	35˙416.67

Mappa

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 Obiettivo del progetto (Objective)

'Schistosomiasis caused by trematode parasites, the Schistosoma bloodflukes, represents one of the most serious chronic infections in the developing world with more then 200 million people infected and many more at risk. Schistosomes reside in the portal and mesenteric or bladder and survive for many years producing hundreds of fertilized eggs per day. Chronic infections can persist for decades and severe morbidity results from host immune responses to eggs in tissues. Disease symptoms include; spleno- and hepatomegalies due to an immune-mediated entrapment (granulomas) of schistosome eggs, periportal fibrosis, portal hypertension, urinary obstruction, bladder carcinoma, sterility, malnutrition, developmental retardation. Resistant isolates of S. mansoni in some regions have been already reported from treated patients. Their evasive and immuno-modulatory strategies are key players in host-parasite interactions. Their bioactive molecules involved in these processes represent interesting subject for pharmacology. One group, proteases function at the host-parasite interface facilitating migration, immune evasion and digestion of host proteins. Besides of relatively well characterized enzymes there are groups of proteases which were surprisingly neglected. One of them is a group which belongs to the class of serine proteases, Clan PA trypsin-like family S1. These schistosomal proteases share similarities to several human regulatory factors such as mammalian kallikrein, epithelial transmembrane proteases, protein C-anticoagulation factor. This probably arose due to co-existence with the mammalian hosts and needs to actively interact with their physiological processes involving proteolysis (anticoagulation, vasodilatation, immuno-evasion). If hypothesis is valid, proteases may represent attractive bioactive pharmacokinetic molecules for further research. At last, it may have impact on better understanding of diseases, leading subsequently to new disease treatments.'

Introduzione (Teaser)

Schistosomiasis is a serious chronic infectious disease afflicting millions of sufferers in the developing world. A European study aimed to find ways of treating the disease or preventing its spread.