HSRRNA

Structural and functional studies of structured RNA involved in heat shock response

 Coordinatore THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE 

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Mr.
Nome: Charles
Cognome: Shannon
Email: send email
Telefono: +44 1223 764189
Fax: +44 1223 332988

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 0 €
 EC contributo 137˙147 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IEF-2008
 Funding Scheme MC-IEF
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-05-06   -   2010-11-05

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Mr.
Nome: Charles
Cognome: Shannon
Email: send email
Telefono: +44 1223 764189
Fax: +44 1223 332988

UK (CAMBRIDGE) coordinator 137˙147.10

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

rna    structural    coding    eukaryotes    heat    shock    recently    intervention    rnas    therapeutic   

 Obiettivo del progetto (Objective)

'The heat shock response is important in eukaryotes as a protective mechanism for the stress of change in temperature or other environmental factors, and it has been the subject for targets for therapeutic intervention. Recently, it has been found that a conserved non-coding RNA is involved in mediating the heat shock response. The RNA forms a stable complex with elongation factor eEF1A to activate the heat shock transcription factor. The project will involve the preparation of recombinant RNA-protein complex for structural elucidation by X-ray crystallography and biochemical and biophysical characterisation. The structural information may help to explain how the RNA triggers the response, most likely through a conformational switch. Currently there is no structural information available for the heat shock RNA or for any of the several other large non-coding RNAs that have recently been identified in eukaryotes. The structural information may help to explain how the heat shock RNA and other non-coding RNAs function, and may also be useful in the long term for therapeutic intervention in response to chemotherapy of cancerous cells.'

Altri progetti dello stesso programma (FP7-PEOPLE)

SMS ENZYME (2010)

Exploring Structure-Function Relationship of Enzymes at Single Molecule Level: Fluorescence and Force Spectroscopy

Read More  

HIMALAYABROWNCARBON (2014)

Quantification and source apportionment of brown carbon aerosols in the high Himalayas

Read More  

MEDPLANT (2013)

Phylogenetic exploration of medicinal plant diversity

Read More