HSRRNA
Structural and functional studies of structured RNA involved in heat shock response
| Coordinatore | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 0 € |
| EC contributo | 137˙147 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-IEF-2008 |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-05-06 - 2010-11-05 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | coordinator | 137˙147.10 |
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Obiettivo del progetto (Objective)
'The heat shock response is important in eukaryotes as a protective mechanism for the stress of change in temperature or other environmental factors, and it has been the subject for targets for therapeutic intervention. Recently, it has been found that a conserved non-coding RNA is involved in mediating the heat shock response. The RNA forms a stable complex with elongation factor eEF1A to activate the heat shock transcription factor. The project will involve the preparation of recombinant RNA-protein complex for structural elucidation by X-ray crystallography and biochemical and biophysical characterisation. The structural information may help to explain how the RNA triggers the response, most likely through a conformational switch. Currently there is no structural information available for the heat shock RNA or for any of the several other large non-coding RNAs that have recently been identified in eukaryotes. The structural information may help to explain how the heat shock RNA and other non-coding RNAs function, and may also be useful in the long term for therapeutic intervention in response to chemotherapy of cancerous cells.'