INVFEST

Evolutionary and functional analysis of polymorphic inversions in the human genome

 Coordinatore UNIVERSITAT AUTONOMA DE BARCELONA 

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 Nazionalità Coordinatore Spain [ES]
 Totale costo 1˙475˙377 €
 EC contributo 1˙475˙377 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-StG
 Funding Scheme ERC-SG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-02-01   -   2015-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAT AUTONOMA DE BARCELONA

 Organization address address: Campus UAB -BELLATERRA- s/n
city: CERDANYOLA DEL VALLES
postcode: 8193

contact info
Titolo: Dr.
Nome: Mario
Cognome: Cáceres
Email: send email
Telefono: +34 93 581 1233
Fax: +34 93 581 2011

ES (CERDANYOLA DEL VALLES) hostInstitution 1˙475˙377.00
2    UNIVERSITAT AUTONOMA DE BARCELONA

 Organization address address: Campus UAB -BELLATERRA- s/n
city: CERDANYOLA DEL VALLES
postcode: 8193

contact info
Titolo: Ms.
Nome: Francisca
Cognome: Rabadán
Email: send email
Telefono: +34 93 581 3752
Fax: +34 93 5813752

ES (CERDANYOLA DEL VALLES) hostInstitution 1˙475˙377.00

Mappa


 Word cloud

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genome    variation    genetic    expression    evolutionary    structural    human    phenotypic    gene    years    functional    inversions   

 Obiettivo del progetto (Objective)

'The last years have seen an extraordinary explosion of studies characterizing genome variation at different levels, and have opened new opportunities in deciphering the genetic basis of phenotypic characteristics and the evolutionary forces involved. One of the major breakthroughs has been the discovery of an unprecedented degree of structural variation in the human genome, including deletions, duplications and inversions. However, the main challenge is to understand the biological significance of these genomic changes. In particular, for many years inversions have been the paradigm of evolutionary biology. Thus, the identification of the whole set of human inversions gives us a unique opportunity to investigate the functional and evolutionary consequences of this type of changes at a large scale. The specific objectives of the project are: (1) Catalogue the precise location of all common polymorphic inversions in the human genome; (2) Determine the population distribution and the evolutionary history of these inversions; (3) Investigate the functional consequences and the effects on gene expression of human inversions; and (4) Assess the effect of inversions on nucleotide variation patterns and the role of natural selection in their maintenance. This project will follow a multidisciplinary approach that combines experimental and bioinformatic analyses and will benefit from the great amount of information on the human genome already available and that will be generated in the next months. The proposed research therefore represents a very appropriate and timely contribution to the study of human structural variation and its role in phenotypic variation and evolution. Furthermore, it will provide additional insights on genome function, gene-expression regulation mechanisms, and the association of genetic changes and particular traits, and promises to stir novel hypothesis for future studies.'

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