LYNX3

Molecular characterization of respiratory epithelium specific Lynx3

 Coordinatore Bilkent Üniversitesi 

 Organization address address: ESKISEHIR YOLU 8 KM
city: ANKARA
postcode: TR-06800

contact info
Titolo: Prof.
Nome: Salim
Cognome: Ciraci
Email: send email
Telefono: -2902735
Fax: -2664587

 Nazionalità Coordinatore Turkey [TR]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-RG
 Funding Scheme MC-IRG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-03-01   -   2014-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Nome Ente NON disponibile

 Organization address address: ESKISEHIR YOLU 8 KM
city: ANKARA
postcode: TR-06800

contact info
Titolo: Prof.
Nome: Salim
Cognome: Ciraci
Email: send email
Telefono: -2902735
Fax: -2664587

TR (ANKARA) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

function    nervous    physiological    family    characterization    modulator    tobacco    lung    proteins    ly    motility    acetylcholine    adhesion    receptors    addictive    nicotinic    disease    recently    lynx    receptor    cellular    cell    nachrs    epithelia    plan    specifically    molecular    anxiety    nicotine    consists    learning   

 Obiettivo del progetto (Objective)

'Tobacco use is the leading preventable cause of death in the world. Nicotine, which is the addictive ingredient of tobacco, exerts its addictive effect through nicotinic acetylcholine receptors (nAChRs) in the central nervous system (CNS). Besides mediating nicotine addiction, nAChRs have been implicated in Alzheimer’s disease, Parkinson’s disease, learning and memory, autism, anxiety disorders, depression, cell motility and cellular adhesion. Lynx1 has recently been identified as a modulator of nAChRs and it functions in nicotinic receptor mediated learning and neurodegeneration. Lynx1 is a member of Ly6 superfamily of proteins (Ly6SF), which is a large protein family that consists of proteins with a characteristic three-finger topology. Lynx family consists of ~100 kDa proteins that function mainly in the nervous system through nicotinic receptor modulation. We have recently identified Lynx2 as another modulator of nicotinic receptor activity which is involved in fear and anxiety related behavior. Lynx3 is a novel member of this family that is expressed in high levels in lung epithelial cells that are specifically important in mechanical sensation. We plan to characterize the molecular function of Lynx3 and its association to lung disease through molecular biological, physiological and behavioral techniques. Our work plan can be grouped under the following headings: 1) Characterization of Lynx3 expression in lung respiratory epithelia and other sensory epithelia. 2) Functional characterization of Lynx3 in vitro through immünoprecipitation experiments and electrophysiology. 3) Physiological analysis of Lynx3 function through targeted-deletion of Lynx3 in mouse models. Our previous work and cited literature suggest that nicotinic acetylcholine receptors are involved in lung physiology, specifically nicotinic receptor associated cellular motility and cell adhesion and Lynx3 is a potential modulator of this system.'

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