PRESYNAPTOGENESIS

The role of local mRNA translation in synapse formation

 Coordinatore CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO 

 Organization address address: UNIVERSIDADE DE COIMBRA .
city: COIMBRA
postcode: 3004 517

contact info
Titolo: Prof.
Nome: Carlos
Cognome: Duarte
Email: send email
Telefono: 351239000000
Fax: 351239000000

 Nazionalità Coordinatore Portugal [PT]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-RG
 Funding Scheme MC-IRG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-04-01   -   2014-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

 Organization address address: UNIVERSIDADE DE COIMBRA .
city: COIMBRA
postcode: 3004 517

contact info
Titolo: Prof.
Nome: Carlos
Cognome: Duarte
Email: send email
Telefono: 351239000000
Fax: 351239000000

PT (COIMBRA) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

neurons    axons    local    mrna    axonal    synapse    shown    translation    cues    neurodevelopmental    recent    protein    mechanisms    differentiation    functional    synthesis    presynaptic   

 Obiettivo del progetto (Objective)

'The objective of the proposed research is to identify the signaling mechanisms that lead to presynaptogenesis, the mechanism by which a functional presynaptic terminal is formed. Postsynaptic mechanisms such as LTF (long-term facilitation) in invertebrate neurons, and LTP (long-term potentiation) and LTD (long-term depression) in mammalian neurons have been well characterized and shown to be dependent on local mRNA translation. However, presynaptic protein synthesis has not been object of intense studies in the past years. Recent studies show that axons can rapidly integrate and respond to local cues by regulating locally protein synthesis. Studies involving axonal protein synthesis in neurodevelopment have focused essentially on the role of local mRNA translation in growth cone collapse. However, recent data has shown that local translation is required for other neurodevelopmental mechanisms like neuronal survival and axonal pathfinding. Also, the observation that distal axons have a diverse mRNA composition leads us to ask if local mRNA translation may play an important role in other neurodevelopmental processes like presynaptic differentiation. In our preliminary studies we addressed this question. We have found that axonal application of FGF22 induces synapse formation in ciliary ganglia motor neurons in culture, as accessed by synapsin clustering. Protein synthesis inhibitors were able to block this effect indicating that local protein translation is required for synapse assembly. However, the mechanisms by which synaptogenic cues lead to the formation of a functional synapse remain unknown. Here we test the hypothesis that presynaptic differentiation occurs through local mRNA translation.'

Altri progetti dello stesso programma (FP7-PEOPLE)

SEMDATA (2013)

Semantic Data Management

Read More  

INTECHSE (2012)

International Network on Integrated Techniques in Structural Elucidation

Read More  

NANOCOAT (2008)

Development of Self-lubricating Nanocomposite Coatings impregnated with in-situ formed MoS2 for Tribological Applications

Read More