MOTOR CIRCUITS

Neuronal circuits controlling motor behavior

 Coordinatore FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH 

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 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 2˙499˙354 €
 EC contributo 2˙499˙354 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-03-01   -   2016-02-29

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Novartis Forschungsstiftung

 Organization address address: Maulbeerstrasse 66
city: BASEL
postcode: 4058

contact info
Titolo: Mrs.
Nome: Dorothy
Cognome: Searles
Email: send email
Telefono: +41 61 6972982
Fax: +41 61 6973976

CH (BASEL) beneficiary 0.00
2    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH

 Organization address address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058

contact info
Titolo: Mrs.
Nome: Dorothy
Cognome: Searles
Email: send email
Telefono: +41 61 6972982
Fax: +41 61 6973976

CH (BASEL) hostInstitution 2˙499˙354.00
3    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH

 Organization address address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058

contact info
Titolo: Prof.
Nome: Silvia Isabelle
Cognome: Arber
Email: send email
Telefono: +41 61 267 2057
Fax: +41 61 267 2078

CH (BASEL) hostInstitution 2˙499˙354.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

genetic    map    animal    anatomical    circuits    principles    neurons    output    neuron    functionally    connectivity    premotor    behavior    specificity    degree    neuronal    generation    pools    motor    circuit    individual    mice   

 Obiettivo del progetto (Objective)

'How does the assembly of neuronal circuits contribute to the emergence of function controlling dedicated animal behaviors? Finding answers to this question requires a deep understanding of the connectivity map of neuronal circuits controlling a behavior as well as the mechanisms involved in the generation of these specific circuit maps. In the project outlined here, I propose the analysis of the neuronal circuits involved in the generation of motor output, a behavior representing the ultimate output of nearly all nervous system activity. Studying the mouse motor output system will allow the analysis of neuronal circuit connectivity at an exquisite degree of specificity. Owing to the anatomical arrangement of motor neuron pools innervating individual muscles, this system offers the possibility to combine genetic, anatomical and physiological analysis of synaptic specificity with a direct link to a behavioral output. Generation of coordinated motor behavior is functionally linked to the high degree of specificity in presynaptic connections controlling the activation of individual motor neuron pools, yet knowledge on the specificity map of premotor circuits is currently missing. The aim of this research project is to acquire information on the general principles guiding the acquisition, maintenance and developmental plasticity of neuronal connectivity between premotor neurons and functionally defined subpopulations of motor neurons. This project is now possible due to the unique combination of our detailed know-how of the motor system in mice including a variety of genetic animal models, and the application of novel viral circuit tracing technology revealing monosynaptically connected premotor neurons, which we have recently applied successfully to the motor system in mice in vivo. Together, our project will elucidate the anatomical connectome of the motor output system as well as the principles governing the specificity with which motor circuits assemble.'

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THE ENDOCYTIC AND CYTOSKELETAL MATRIX IN THE PLASTICITY OF TUMOR CELL INVASION AND MIGRATION

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