DNADEMETHYLASE

Functions and mechanism of active DNA demethylation

 Coordinatore INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH 

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 Nazionalità Coordinatore Germany [DE]
 Totale costo 2˙376˙000 €
 EC contributo 2˙376˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-06-01   -   2015-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Ms.
Nome: Elke
Cognome: Luksch
Email: send email
Telefono: -428888
Fax: -428880

DE (HEIDELBERG) beneficiary 175˙000.00
2    INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH

 Organization address address: ACKERMANNWEG 4
city: MAINZ
postcode: 55128

contact info
Titolo: Ms.
Nome: Franziska
Cognome: Martin
Email: send email
Telefono: +49 6131 39 21453
Fax: +49 6131 39 21521

DE (MAINZ) hostInstitution 2˙201˙000.00
3    INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH

 Organization address address: ACKERMANNWEG 4
city: MAINZ
postcode: 55128

contact info
Titolo: Prof.
Nome: Heinz Christof
Cognome: Niehrs
Email: send email
Telefono: +49 6131 39 21400
Fax: +49 6131 39 21521

DE (MAINZ) hostInstitution 2˙201˙000.00

Mappa


 Word cloud

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regulation    binding    protein    progress    central    dna    mouse    gadd    mechanism    unresolved    genes    demethylation    analyze    gene   

 Obiettivo del progetto (Objective)

'Epigenetic gene regulation is of central importance for development and disease. Despite dramatic progress in epigenetics during the past decade, DNA demethylation remains one of the last big frontiers and very little is known about it. DNA demethylation is a widespread phenomenon and occurs in plants as well as in animals, during development, in the adult, and during somatic cell reprogramming of pluripotency genes. The molecular identity of the DNA demethylase in animal cells remained unresolved and has hampered progress in the field for decades. In 2007 we published that Growth Arrest and DNA Damage 45 a (Gadd45a) is a key player in active DNA demethylation, which opened new avenues in the study of this elusive process. The goal of this project is to further analyze the mechanism of DNA demethylation as well as the role played by Gadd45 in development. Given the many unresolved questions in this burgeoning field, our work promises to be ground-breaking and therefore have a profound impact in unraveling one of the least understood processes of gene regulation. Specifically we will address the following points. I) The biological role of Gadd45 mediated DNA demethylation in mouse embryos and adults is unknown. We have obtained mouse mutants for Gadd45a,b, and g and we will analyze them for developmental defects and dissect the methylation regulation of relevant genes. II) The targeting mechanism by which Gadd45 is binding to and demethylating specific sites in the genome is a central unresolved issue. We have identified a candidate DNA binding protein interacting with Gadd45 and we will analyze its role in site specific targeting of DNA demethylation in vitro and in mouse. III) We found that Gadd45 is an RNA binding protein and we will therefore analyze how non-coding RNAs are involved in targeting and/or activating Gadd45 during DNA demethylation.'

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