TELOMERES IN MEIOSIS

Telomere function in meiosis

Coordinatore	CANCER RESEARCH UK    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	1˙451˙943 €
EC contributo	1˙451˙943 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2009-AdG
Funding Scheme	ERC-AG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-06-01   -   2015-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CANCER RESEARCH UK  Organization address address: ST JOHN STREET 407 ANGEL BUILDING city: LONDON postcode: EC1V 4AD contact info Titolo: Dr. Nome: Julia Promisel Cognome: Cooper Email: send email Telefono: +44 2 072693415 Fax: +44 2 072693258	UK (LONDON)	hostInstitution	1˙451˙943.00
2	CANCER RESEARCH UK  Organization address address: ST JOHN STREET 407 ANGEL BUILDING city: LONDON postcode: EC1V 4AD contact info Titolo: Ms. Nome: Holly Cognome: Elphinstone Email: send email Telefono: 442073000000 Fax: 442073000000	UK (LONDON)	hostInstitution	1˙451˙943.00

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 Obiettivo del progetto (Objective)

'Telomeres have long been known to play crucial roles in protecting chromosome ends from attrition and fusion and thus safeguarding genome stability, but their complete functional repertoire has yet to be fully understood. Among the fundamental roles of telomeres is their role in meiosis, the process by which parental genomes are recombined and halved, allowing the generation of genetic diversity via sexual reproduction. As cells progress from mitotic to meiotic cycles, telomere functions change radically as all telomeres gather to a small region of the nuclear periphery near the centrosome to form the telomere bouquet . While this bouquet is widely conserved, the challenges of manipulating meiosis in most eukaryotes has made bouquet function a matter of speculation until recently. We utilize the fission yeast Schizosaccharomyces pombe as a model to study telomeres, as this organism provides a powerful combination of genetic manipulability and striking conservation of chromosomal structure/function with human. Recently, we made the unexpected discovery that the bouquet controls the behavior of meiotic centrosomes and spindles. Furthermore, we find that the bouquet is required not only for proper spindle formation, but also for attachment of meiotic chromosomes to the spindle via their centromeres. Using molecular genetics, quantitative live analysis and biochemistry, we propose to define the mechanisms by which the gathered telomeres control spindle behavior. We will also investigate what aspect of the telomere confers proper centromere-spindle attachment and what goes wrong at centromeres in cells lacking the bouquet. These studies will illuminate mechanisms of communication between chromosomes and the spindle apparatus that should be widely conserved among eukaryotes.'